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  1. Is it time for a change? The case for early application of unrelated allo-SCT for severe aplastic anemia.

    ... curative option. Its application remains limited by donor availability and by the potential for treatment-related morbidity and mortality. The improved outcomes with unrelated transplantation are a result of the advent of molecular ... registry. Decision making regarding the earlier use of unrelated transplant procedures is rapidly evolving. This paper reviews ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Pilot trial of risk-adapted cyclophosphamide intensity based conditioning and HLA matched sibling and unrelated cord blood stem cell transplantation in newly diagnosed pediatric and adolescent recipients with acquired severe aplastic anemia

    ... patients with acquired SAA incorporating alternative donor sources, including cord blood. Average risk for non- engraftment ... included MRD BM (6/6 [n = 9], 5/6 [n = 2]) and unrelated CB (5/6 [n = 4], 4/6 [n = 2]). Five year OS was 67.6% ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Allogeneic transplantation for aplastic anemia

    ... severe aplastic anemia, HLA -matched sibling, unrelated donor , hematopoietic stem cell transplantation. RESULTS: Survival ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Reduced dose cyclophosphamide, fludarabine and antithymocyte globulin for sibling and unrelated transplant of children with severe and very severe aplastic anemia.

    ... disease severity (SAA vs. VSAA, p = 0.184), or according to donor type (MSD vs. UD, p = 0.699). Excellent outcomes of patients with VSAA ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Impact of donor source on hematopoietic cell transplantation outcomes for patients with myelodysplastic syndromes (MDS)

    ... leukocyte antigen ( HLA ) matched related donor (MRD) and matched unrelated donors (MUD) produces similar survival for patients with acute ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Aplastic anemia: therapeutic updates in immunosuppression and transplantation

    ... in the matched setting, but with greater rates observed with unrelated and umbilical cord donors. The correlation of increasing age with the ... in adults with SAA. Outcomes with matched unrelated donor HSCT have improved, likely due to better donor selection, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Hematopoietic stem cell transplantation for aplastic anemia and paroxysmal nocturnal hemoglobinuria: current evidence and recommendations

    ... is the preferred option for young AA patients with a sibling donor, whereas in older patients or in those to be grafted from an unrelated donor BMT is exploited as second-line treatment. Current results of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Allogeneic haematopoietic stem cell transplantation in myelodysplastic syndromes

    ... human leukocyte antigen -identical sibling or match unrelated donor options. A preemptive management approach to patients at high risk ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Myelodysplastic syndromes: who and when in the course of disease to transplant

    ... disease-free survival. In recent years, alternative donor sources have been demonstrated to be a viable alternative to traditional sibling and matched unrelated donor stem cell sources. Efforts at transplantation regimen ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. The diagnosis and treatment of aplastic anemia: a review

    ... therapy for patients <40 years when a matched sibling donor (MSD) is not available for transplant. MSD hematopoietic stem cell ... but a response rate of about 60 %. Front-line matched unrelated donor (MUD) appears to be a viable option in children with ...

    Research Article last updated 07/20/2018 - 5:15pm.