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  1. A Phase 1 Study of Oral ARRY-614, a p38 MAPK/Tie2 Dual Inhibitor, in Patients with Low or Intermediate 1 Risk Myelodysplastic Syndromes

    ... patients experiencing bilineage responses. Three of 25 RBC transfusion-dependent (TD) patients achieved transfusion independence (TI) and 5 of 7 platelet TD patients achieved TI. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence

    ... transfusions can improve anemia ; however, prolonged transfusion dependence (TD) is associated with increased morbidity and ... start of TD) on the likelihood of achieving transfusion independence (TI) among 508 TD patients with MDS. Mean time to DMT was ...

    Research Article last updated 09/13/2017 - 8:58am.

  3. FDA approves new drug for relapsed or refractory AML

    ... recovery (CRh) rates, CR/CRh duration, and conversion from transfusion dependence to transfusion independence were the basis of approval. After a median follow-up time ...

    Article last updated 08/30/2017 - 8:30am.

  4. Patterns of treatment and costs associated with transfusion burden in patients with myelodysplastic syndromes.

    ... Transfusion dependence (TD) among myelodysplastic syndromes (MDS) ... cost patterns of MDS care during TD and transfusion independence (TI). MDS patients were identified from a US claims database ...

    Research Article last updated 05/22/2017 - 11:01am.

  5. Lenalidomide use in myelodysplastic syndromes: Insights into the biologic mechanisms and clinical applications

    ... of chromosome 5 (5q-), where it leads to high rates of transfusion independence and cytogenetic responses. Furthermore, lenalidomide delays ...

    Research Article last updated 02/21/2017 - 9:34am.

  6. Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes

    ... hematologic improvement, 12 of 32 patients attained RBC transfusion independence and 7 of 18 attained platelet transfusion ...

    Research Article last updated 02/03/2017 - 10:05am.

  7. How I treat acquired aplastic anemia

    ... with immunosuppressive agents (IST), leading to transfusion independence , or complete recovery of peripheral blood counts, in a ...

    Research Article last updated 02/03/2017 - 9:51am.

  8. Treatment of low-risk myelodysplastic syndromes

    ... of IPSS-R, endogenous erythropoietin levels, and transfusion independence . Doses and duration of therapy of erythropoietic-stimulating ...

    Research Article last updated 01/26/2017 - 10:42am.

  9. Eltrombopag versus placebo for low-risk myelodysplastic syndromes with thrombocytopenia (EQoL-MDS): phase 1 results of a single-blind, randomised, controlled, phase 2 superiority trial.

    ... need for early trial termination. Duration of platelet transfusion independence, duration of response, overall survival, leukaemia-free survival, ...

    Research Article last updated 02/21/2017 - 9:49am.

  10. Efficacy and Safety of Lenalidomide for Treatment of Low-/Intermediate-1-Risk Myelodysplastic Syndromes with or without 5q Deletion: A Systematic Review and Meta-Analysis

    ... could effectively induce red blood cell (RBC) transfusion independence (TI) in patients with lower-risk (Low/Intermediate-1) ...

    Research Article last updated 11/28/2016 - 9:36am.