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  1. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... , bone marrow failure and a propensity for thrombosis . These patients experience both intra- and extravascular ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria

    ... complications of chronic hemolysis , recurrent thrombosis , marrow failure, serious infections, abdominal pain, chronic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . Seventeen patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Baseline characteristics and disease burden in patients in the international paroxysmal nocturnal hemoglobinuria registry

    ... hemolytic anemia , bone marrow failure , thrombosis , and, frequently, poor quality of life. The International PNH ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... associated with pancytopenia or venous thrombosis . This disorder is a consequence of acquired somatic mutations in ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... Prophylaxis and treatment of arterial and venous thrombosis currently remain a challenge in PNH. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... , nor did they experience hemolysis or thrombosis , and they did not require specific interventions with ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... esophageal spasm , fatigue, and possibly thrombosis . Aerolysin is a pore-forming toxin that binds GPI-anchored ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Loss of expression of neutrophil proteinase-3: a contributory factor in thrombotic risk in paroxysmal nocturnal hemoglobinuria.

    ... proteinase 3 levels, clone size and history of thrombosis . In addition, we found that treating platelets ex vivo with ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Decreased plasma cytokines associate with low platelet counts in aplastic anemia and immune thrombocytopenic purpura

    ... platelet disorders. © 2012 International Society on Thrombosis and Haemostasis. ...

    Research Article last updated 07/20/2018 - 5:14pm.