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  1. Aplastic anemia and risk of deep vein thrombosis and pulmonary embolism: A nationwide cohort study

    ... OBJECTIVES: Deep vein thrombosis (DVT) and pulmonary embolism (PE) constitute venous ...

    Research Article last updated 01/24/2017 - 12:40pm.

  2. Selective splenic artery embolization for the treatment of thrombocytopenia and hypersplenism in paroxysmal nocturnal hemoglobinuria

    ... BACKGROUND: PNH is associated with abdominal vein thrombosis , which can cause splenomegaly and hypersplenism. The combination of thrombosis, splenomegaly, and thrombocytopenia (TST) is challenging ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... hemolysis , aplasia and an increased risk of thrombosis . We describe a patient under treatment with the anti-complement ... complications of splenectomy, especially that of thrombosis. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... intravascular hemolysis and reduce the risk of thrombosis . DESIGN AND METHODS: This is a retrospective, ... and lactate dehydrogenase <1.5 upper limit of normal without thrombosis. These patients did not achieve normal hemoglobins for age and sex. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria.

    ... with chronic hemolysis , anemia , and thrombosis . Renal damage in PNH is associated with chronic hemosiderosis and/or microvascular thrombosis. We determined the incidence of renal dysfunction or damage, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. How I treat paroxysmal nocturnal hemoglobinuria.

    ... hemolytic anemia , bone marrow failure , and thrombosis . Many of the clinical manifestations of the disease result from ... improving quality of life, and reducing the risk for thrombosis in PNH patients. Insights into the relevance of detecting PNH cells ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... and morbidities that include anemia , thrombosis , renal impairment, pulmonary hypertension, and bone marrow ... attack contributes to additional complications, such as thrombosis. Eculizumab , a humanized monoclonal antibody against ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Long term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: sustained efficacy and improved survival.

    ... to PNH. Twenty-one of the 79 patients (27%) had a thrombosis prior to starting eculizumab (5.6 events per 100 patient years) ... p<0.001). Twenty-one patients with no prior history of thrombosis discontinued warfarin after starting eculizumab with no ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... uncontrolled complement activation, a propensity for thrombosis and marrow failure. The hemolysis is largely mediated by ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Paroxysmal nocturnal hemoglobinuria

    ... disorder that manifests with hemolytic anemia , thrombosis and peripheral blood cytopenias. The absence of two ...

    Research Article last updated 07/20/2018 - 5:15pm.