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  1. Thrombosis in Paroxysmal Nocturnal Hemoglobinuria - insights into the role of complement in thrombosis.

    Journal Title:  Thromb Res Primary Author:  Weitz IC Author(s):  Weitz IC ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Erythropoiesis-stimulating agents are not associated with increased risk of thrombosis in patients with myelodysplastic syndromes

    ... Background. There are limited reports of thrombosis among myelodysplastic syndrome patients exposed to ... stimulating agents are associated with an increased risk of thrombosis in myelodysplastic syndromes , as they are among patients ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Cerebral venous thrombosis in paroxysmal nocturnal hemoglobinuria: a series of 15 cases and review of the literature

    ... and a high incidence of life-threatening venous thrombosis . Cerebral venous system is the second most frequent location of thrombosis after hepatic veins. However, data about PNH-related cerebral ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Thrombosis in paroxysmal nocturnal hemoglobinuria.

    ... of paroxysmal nocturnal hemoglobinuria (PNH) is thrombosis . Recent research has demonstrated that the complement and ... complement. This may explain some of the complexity of the thrombosis in PNH. In this review the recent changes in our understanding of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... another prominent feature is a highly increased risk of thrombosis . Thrombosis in PNH results in high morbidity and mortality. Often, thrombosis ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Thrombosis in patients with paroxysmal nocturnal hemoglobinuria.

    ... with hemolysis , pancytopenia , and thrombosis due to the loss of the glycosylphosphatidylinositol (GPI) anchored complement regulatory proteins. The mechanism of thrombosis is multifactorial. Although intravascular hemolysis has been ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Clinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry.

    Journal Title:  Int J Hematol Primary Author:  Lee JW Author(s):  Lee JW, Jan...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Management of thrombosis in paroxysmal nocturnal hemoglobinuria: a clinician's guide

    ... by haemolysis, bone marrow failure and thrombosis . Patients with PNH prior to the availability of eculizumab had a median survival of between 10 and 22 years, with thrombosis accounting for 22-67% of deaths. 29-44% of patients had at least one ...

    Research Article last updated 03/22/2017 - 2:43pm.

  9. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... marrow failure , intravascular hemolysis , and thrombosis . To further characterize the clinical presentation and outcome ... excessive blasts or leukemic transformation. Thrombosis occurred in 6 patients. Five patients underwent hematopoietic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Evaluation of hemostasis and endothelial function in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab.

    ... (PNH) is associated with an increased risk of thrombosis through unknown mechanisms. DESIGN AND METHODS: We ... the patients, including those with no history of clinical thrombosis. Treatment with eculizumab was associated with significant ...

    Research Article last updated 07/20/2018 - 5:14pm.