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  1. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    ... VAF predicted for monocytosis (P=0.003), RUNX1 VAF with thrombocytopenia (P=0.01) and SF3B1 with ringed sideroblasts (P=0.001). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Clinical effect of point mutations in myelodysplastic syndromes

    ... TP53, and NRAS were most strongly associated with severe thrombocytopenia (P<0.001 for all comparisons) and an increased proportion ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Bone marrow hypocellularity does not affect tolerance or efficacy of azacitidine in patients with higher-risk myelodysplastic syndromes

    ... was similar regardless of cellularity. Grade 3-4 thrombocytopenia and neutropenia occurred similarly in ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy.

    ... a dose of 60 mg/m(2) was well tolerated. Grade III-IV thrombocytopenia and neutropenia occurred after 9.5 and 30% of the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Phase II clinical study of erlotinib for treatment of myelodysplastic syndromes

    ... (17.1%), and infection (11.6%), accompanied by fatigue, thrombocytopenia , and anorexia at 5.7% each. Median overall survival was ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Altered immunophenotypic features of peripheral blood platelets in myelodysplastic syndromes.

    ... alterations (score>1.5; n=16) who more frequently showed thrombocytopenia , megakaryocytic dysplasia and high-risk disease, together ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Simona Pagliuca, MD

    ... ), white blood cells (leukopenia), and platelets ( thrombocytopenia ). If untreated, this disease has a high risk of death. ... ), white blood cells (leukopenia), and platelets ( thrombocytopenia ). If untreated, this disease has a high risk of severe ...

    Grant Recipient last updated 08/15/2018 - 12:22pm.

  8. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of thrombopoietin receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO ... in fatigue and exacerbation of heart conditions, and thrombocytopenia in bleeding. Bone marrow transplantation is the only ...

    Research Review last updated 05/02/2016 - 9:21am.

  9. Symptoms

    ... A low platelet count is called thrombocytopenia . If you have a low platelet count, you may: Bruise ...

    Topic section last updated 09/14/2018 - 2:46pm.

  10. ASCO Updates Platelet Transfusion Guideline Prophylaxis unnecessary for adults undergoing HSCT

    ... treatment of bleeding in patients with treatment-related thrombocytopenia but also sought to avoid the overuse of platelet ... the risk of bleeding from chemotherapy -induced thrombocytopenia in patients with solid tumors - a platelet threshold of <10 x ...

    Research Article last updated 12/06/2017 - 11:23am.