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  1. The clinical importance of moderate/severe bone marrow fibrosis in patients with therapy-related myelodysplastic syndromes.

    ... in patients with primary myelodysplastic syndromes (MDS). However, the clinical importance of BM fibrosis is not clear in therapy-related MDS . We retrieved all therapy-related MDS (t-MDS) cases ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases

    ... sequencing-based approach to profile gene mutations in therapy-related myelodysplastic syndromes (t-MDS) and acute myeloid leukemia (t-AML); and compared these findings with ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases

    ... BACKGROUND: TP53 mutation is more prevalent in therapy-related myeloid neoplasms (t-MN) than their de novo ... patients with therapy-related myelodysplastic syndrome (t-MDS)/acute myeloid leukemia (t-AML). Clinical, hematological, and cytogenetic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia

    ... Therapy-related myelodysplastic syndromes and acute myelogenous leukemia (t-MDS/AML) comprise a poor-risk subset of MDS/AML. Large scale mutation ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Allogeneic stem cell transplantation in therapy-related acute myeloid leukemia and myelodysplastic syndromes: impact of patient characteristics and timing of transplant

    ... Patients with therapy-related acute myeloid leukemia (t-AML) and myelodysplastic syndromes (t-MDS) have poor survival and high non-relapse mortality (NRM) after allogeneic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Recent advances in the management of therapy-related myelodysplastic syndromes and acute myeloid leukemia.

    ... PURPOSE OF REVIEW: Therapy-related myelodysplastic syndromes and acute myelogenous leukemia (t-MDS/AML) comprise an increasingly common, poor-risk disease cohort without ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Radiation alone for solid tumors and the questionable development of therapy-related myelodysplastic syndromes

    ... myelodysplastic syndromes (MDS) ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Application of the International Prognostic Scoring System-Revised (IPSS-R) in Therapy-related Myelodysplastic Syndromes and Oligoblastic Acute Myeloid Leukemia.

    ... myelodysplastic syndromes (MDS) ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Mesenchymal stromal cell density is increased in higher grade myelodysplastic syndromes and independently predicts survival

    ... to evaluate for myelodysplastic syndromes (MDS). METHODS: CD271+ MSC density was quantitated by automated image ... Scoring System (IPSS-R), history of transfusion, therapy-related MDS , and fibrosis (hazard ratio, 3.4; P < .001). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndromes

    ... with curative potential for myelodysplastic syndrome (MDS). The availability of SCT has been expanded with the introduction of ... with intermediate-2 and high-risk disease and those with therapy-related MDS have a poor prognosis with alternative therapies; ...

    Research Article last updated 07/20/2018 - 5:15pm.