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  1. Dr. Kasiani Myers: Acquired and Inheirited Bone Marrow Failure

    ... translate the protein in our bodies) and others involve telomere diseases (the ends of our chromosomes that protect our ...

    Interview last updated 02/14/2017 - 8:34am.

  2. Improved Outcome of Reduced Toxicity Fludarabine, Cyclophosphamide Plus Thymoglobulin Conditioning Regimen for Unrelated Donor Transplantation in Severe Aplastic Anemia: Comparison of Two Multicenter Prospective Studies

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract #220 Oral ...

    Research Review last updated 05/02/2016 - 9:24am.

  3. Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract #1259 ...

    Research Review last updated 05/02/2016 - 9:23am.

  4. AAMDSIF Scientific Symposium 2016 Presentations

    ... in the Genomic Era 496.99 KB Telomere Modulation in Vivo 3.51 MB Immunodeficiency ...

    Page last updated 08/17/2016 - 3:32pm.

  5. Radiation- and Alkylator-free Bone Marrow Transplantation Regimen for Patients With Dyskeratosis Congenita

    ... and oral leukoplakia. DC is part of a spectrum of telomere biology disorders, which include some forms of inherited ...

    Clinical Trial last updated 04/27/2016 - 8:49am.

  6. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... (changes) in genes and unstable chromosomes (measured by telomere length) in 43 patients with aplastic anemia. Aplastic anemia had ... the activity of telomerase, an enzyme that maintains telomere length, might reduce the risk of cancer in patients with aplastic ...

    Research Review last updated 05/02/2016 - 9:20am.

  7. Scientific Symposium Co-Chair Richard Stone, MD Discusses Progress and New Directions in Bone Marrow Failure Disease Research

    ... by mutation in genes encoding for members of the telomere complex. A ribosomopathy can also produce bone marrow failure, ... aplastic anemia, whether on an autoimmune basis or due to a telomere problem, we can use different therapies for those different categories ...

    Interview last updated 04/29/2014 - 12:01pm.

  8. Pathogenesis of MDS: An overview of molecular and non-molecular aspects of the disease

    ... the bone marrow microenvironment, apoptosis, cytokines, telomere length, and immune factors.  Conclusions: MDS is ...

    Research Review last updated 05/02/2016 - 9:14am.

  9. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... with bone marrow failure syndromes (BMFS) - telomere length, TERC and TERT mutations was done on protocol ... genes associated with bone marrow failure syndromes (BMFS) - telomere length, TERC and TERT mutations was done on protocol 04-H-0012 at the ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  10. Luis Batista, PhD

    ... derived from bone marrow failure patients that have telomere attrition as a platform for the development of clinical therapies ... the human lifetime. When a cell reaches a critical telomere length, after several rounds of division, it becomes unable to ...

    Grant Recipient last updated 06/09/2015 - 9:22am.