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  1. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... in MDS and its relation to telomerase activity, telomere length and hTERT expression. The telomere length in PBMCs of patients with MDS cases was significantly shorter ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Aplastic Anemia & MDS International Foundation: Bone marrow failure disease scientific symposium 2012

    ... cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex ... in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Somatic mutations identify a sub-group of aplastic anemia patients that progress to myelodysplastic syndrome

    ... DNA. We excluded Fanconi anemia , mutations of telomere maintenance, and a family history of bone marrow failure ... disease duration (37 vs. 8 months, p<0.04), and shorter telomere lengths (median T/S length, 0.9 vs. 1.1, p<0.001), compared to ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Aplastic anemia: pathophysiology and treatment.

    ... the pathogenesis of AA have identified defective telomere maintenance as an important explanation for the onset of marrow ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Impaired proliferative potential of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes is associated with abnormal WNT signaling pathway

    ... CDKN2A, CDKN2B, along with PARG1, whereas the mean telomere length was up-regulated in patient MSCs. MDS-derived MSCs ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Clinical and Genetic Heterogeneity of Telomere Diseases

    ... of bone marrow failure syndromes associated with telomere abnormalities and the role of telomere abnormalities in aplastic anemia . Abstract Number ... failure clinic since 2003. She found that mutations in telomere genes can be found in patients even without family history and should ...

    Research Review last updated 05/02/2016 - 9:24am.

  7. Diagnosis and treatment of pediatric acquired aplastic anemia (AAA): An initial survey of the North American Pediatric Aplastic Anemia Consortium (NAPAAC)

    ... response. Areas of controversy included the need for telomere length results prior to IST, the time after IST initiation ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Telomere Length and Allogeneic Hematopoietic Cell Transplantation for Severe Aplastic Anemia

    ... PubMed Abstract:  Telomere length in hematopoietic stem cell transplantation for severe aplastic ... abbreviated the cell stops proliferating. Consequently, telomere length is a marker of cellular replicative capacity, senescence, ...

    Research Review last updated 05/02/2016 - 9:13am.

  9. Foundation Update - August 2017

    ... Louis, recently published significant research on telomere length in childhood bone marrow failure . He has now been ... Webinars? > What are Telomeres? Exploring Telomere Length in Aplastic Anemia ; September 21, 2017, 1:00 PM ...

    Article last updated 09/05/2017 - 10:53am.

  10. Prognostic value of telomere attrition in patients with aplastic anemia

    ... Abstract:  Prognostic value of telomere attrition in patients with aplastic anemia. ... (PNH) clone and reticulocyte count. Telomere length measurements are another example of a potentially useful ...

    Research Review last updated 05/02/2016 - 9:25am.