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  1. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... cancer development. The clinical relevance of varying telomere lengths (TL) and/or mutations in genes of the telomerase complex ... in telomerase genes. The possibility of modulating telomere attrition rate with sex hormones could positively affect clonal ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Paroxysmal nocturnal hemoglobinuria and telomere length predicts response to immunosuppressive therapy in pediatric aplastic anemia

    ... nocturnal hemoglobinuria populations and a short telomere length were identified as predictive biomarkers of ... The paroxysmal nocturnal hemoglobinuria populations and telomere length were detected by flow cytometry . Forty-seven patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... in tissue culture and animal models. Variations in telomere length have been reported in severe aplastic anemia but ... OBJECTIVE: To investigate the relationship between telomere length and clinical outcomes in severe aplastic anemia. DESIGN, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Telomere length in myelodysplastic syndromes

    ... The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes ... studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Low Dose Danazol for the Treatment of Telomere Related Diseases

    ... danazol can be used to treat people with short telomere disease who also have bone marrow failure , liver, or lung ... danazol, at high doses, showed a positive influence on telomere length. Additional research is needed to learn more about the role of ...

    Clinical Trial last updated 05/31/2018 - 2:53pm.

  6. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia: is it ready for "prime time"?

    Journal Title:  JAMA Primary Author:  Saad A Author(s):  Saad A, Mineishi S, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Short telomeres: from dyskeratosis congenita to sporadic aplastic anemia and malignancy.

    ... subjected to DNA repair activities that would result in telomere fusion, degradation, or recombination. Both the DNA and protein components of the telomere are required for this essential function, because insufficient ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Short telomeres result in chromosomal instability in hematopoietic cells and precede malignant evolution in human aplastic anemia.

    ... In cell and animal models, telomere erosion promotes chromosomal instability via ... epidemiological and indirect. Here we directly implicate telomere shortening as a critical molecular event for malignant evolution in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Telomere length in hematopoietic stem cell transplantation for severe aplastic anemia: is it ready for "prime time"?

    Journal Title:  JAMA Primary Author:  Saad A Author(s):  Saad A, Mineishi S, ...

    Research Article last updated 03/03/2015 - 11:53am.

  10. Telomerase, hTERT and splice variants in patients with myelodysplastic syndromes

    ... in MDS and its relation to telomerase activity, telomere length and hTERT expression. The telomere length in PBMCs of patients with MDS cases was significantly shorter ...

    Research Article last updated 07/20/2018 - 5:15pm.