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  1. Risk stratification in myelodysplastic syndromes: is there a role for gene expression profiling?

    ... expression-based prognostic markers in the hematopoietic stem cells of patients with myelodysplastic syndromes . J Clin Oncol 31(28), ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Pathophysiology, diagnosis, and treatment of paroxysmal nocturnal hemoglobinuria: a review

    ... (PNH) is an acquired disorder of the hematopoietic stem cell that makes blood cells more sensitive to the action of complement. Patients experience ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Eltrombopag in aplastic anemia

    ... that this drug works by directly stimulating marrow stem and progenitor cells thereby promoting hematopoietic recovery in patients with bone ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder primarily affecting CD34+ cells, characterized by ineffective hematopoiesis , often transforming ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Common polymorphic deletion of glutathione S-transferase theta predisposes to acquired aplastic anemia: Independent cohort and meta-analysis of 609 patients.

    ... syndrome, caused by autoimmune destruction of hematopoietic stem and progenitor cells. Epidemiologic studies suggest that environmental exposures and metabolic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Myelodysplastic syndromes in older adults.

    ... that affect the hematopoietic development of myeloid cells in the bone marrow . Although this disorder is curable by way of allogeneic stem cell transplantation, advanced age, limited donor availability, and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Horse versus rabbit antithymocyte globulin in acquired aplastic anemia

    ... of immune-mediated destruction of bone marrow stem and progenitor cells. Immunosuppressive therapy with antithymocyte globulin (ATG) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Optimizing therapy for iron overload in the myelodysplastic syndromes: recent developments.

    ... MDS patients eventually require transfusion of red blood cells for anaemia, placing them at risk of transfusional iron overload . ... may impact adversely on the outcome of higher-risk MDS and stem cell transplantation (SCT). This effect may be due to increased ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... The decision to pursue hematopoietic stem cell transplantation or immunosuppression as first therapy in severe ... insight into genomic instability of bone marrow cells derived from patients with critically short telomeres and/or mutation ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Allogeneic transplantation for aplastic anemia

    ... -matched sibling, unrelated donor , hematopoietic stem cell transplantation. RESULTS: Survival after HLA-matched ... complications. The use of peripheral blood progenitor cells has also contributed to higher GVHD risks and consequently excess ...

    Research Article last updated 07/20/2018 - 5:14pm.