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  1. New therapeutics for myelodysplastic syndromes

    ... MDS is characterized by impaired bone marrow stem cell function, resulting in low blood counts, increased rates of infection ... well as to imbalances among the surrounding, non-cancerous cells (the “MDS microenvironment”).  In this model, progression of an ...

    Research Review last updated 05/02/2016 - 9:28am.

  2. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... understood, but incomplete elimination of auto-reactive T cells and insufficient stem cell reserve are both possible. Furthermore, 10-15% of SAA patients ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  3. What are the treatments for PNH?

    ... This reduces hemolysis , the destruction of red blood cells. Bone marrow/stem cell transplantation (BMT/SCT):  A procedure that replace your unhealthy ...

    FAQ last updated 03/15/2016 - 11:32pm.

  4. Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT (RIC HSCT NMD)

    ... bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) in patients with non-malignant disorders that ... pre-cryopreservation total nucleated cell dose of > 3 x 107 cells/kg, or double unit grafts, each cord blood unit delivering at least ...

    Clinical Trial last updated 06/13/2016 - 2:18pm.

  5. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... post-transplant with MLN9708 to both sensitize tumor cells to NK cytotoxicity and protect against graft-versus-host disease ... reconstitution following haploidentical peripheral blood stem cell transplantation. Patients will receive a nonmyeloablative ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  6. GVAX vs. Placebo for MDS/AML After Allo HSCT

    ... your MDS or AML from relapsing after your allogeneic stem cell transplantation. "Investigational" means that the vaccine is still ... treatment for MDS/AML. It can be effective because the cells from your donor (also known as the graft) could form a new immune system ...

    Clinical Trial last updated 04/28/2016 - 12:01pm.

  7. Total Marrow and Lymphoid Irradiation and Chemotherapy Before Donor Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Leukemia

    ... given together with chemotherapy before donor stem cell transplant in treating patients with myelodysplasticsyndrome or ... as total marrow and lymphoid irradiation, to kill cancer cells, but these treatment kills normal cells as well. After chemotherapy, ...

    Clinical Trial last updated 04/29/2016 - 12:58pm.

  8. Lisa Minter, MD

    ... aplastic anemia , results in the destruction of blood stem and progenitor cells in the bone marrow. One subset of these cells, CD4 T cells, requires the ...

    Grant Recipient last updated 08/18/2014 - 10:07am.

  9. Immunosuppressive Therapy

    ... may prevent the bone marrow from making normal blood cells. Immunosuppressive therapy uses medicines to keep the immune system from ... are turned off by the cyclosporine, they stop attacking stem cells in the bone marrow. Then the stem cells may be able to ...

    Page last updated 01/20/2015 - 4:45pm.

  10. Aplastic Anemia Clinical Trial at the NIH

    ... may also cause the body to make more red and white blood cells. In a trial performed at the NIH where patients with severe aplastic ... suggest that eltrombopag may stimulate hematopoietic stem cells , not just the cells that make platelets, which is a very ...

    Research Review last updated 05/02/2016 - 9:26am.