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  1. A Prospective Multicenter Study of Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure.

    ... hemoglobinuria (PNH), a rare clonal hematopoietic stem cell disorder, is characterized by chronic, uncontrolled complement ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. The complex pathophysiology of acquired aplastic anemia

    ... Immune mediated destruction of hematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Disease progression in myelodysplastic syndromes: do mesenchymal cells pave the way?

    ... Journal Title:  Cell Stem Cell Primary Author:  ... permissive niche has been implicated. In this issue of Cell Stem Cell, Medyouf et al. (2014) provide insights into the role of the niche ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Novel strategies to prevent relapse after allogeneic haematopoietic stem cell transplantation for acute myeloid leukaemia and myelodysplastic syndromes

    ... of haematological neoplasms after allogeneic haematopoietic stem cell transplantation (HSCT) remains one of the leading causes of death. ... interventions to impair growth of residual clonal cells and post-HSCT immune-mediated interventions to enhance the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Myelodysplastic syndromes with 5q deletion: pathophysiology and role of lenalidomide

    ... Myelodysplastic syndrome (MDS) is a hematopoietic stem cell disorder primarily affecting CD34+ cells, characterized by ineffective hematopoiesis , often transforming ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... Glycan class A (PIG-A) gene in the hematopoietic stem cells (HSC) of patients. The presence of these mutations leads to ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... cytopenia and a profound deficit in hematopoietic stem cells and progenitor cells. Thrombopoietin may increase the number of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells

    ... and isogenic karyotypically normal induced pluripotent stem cells (iPSCs) from hematopoietic cells of MDS patients and show that the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going

    ... disorder characterized by the expansion of hematopoietic stem cells and progeny mature blood cells which are deficient in some surface ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. CSNK1A1 mutations and gene expression analysis in myelodysplastic syndromes with del(5q).

    ... β-catenin activation and expansion of haematopoietic stem cells (HSC). We have screened a large cohort of 104 del(5q) MDS patients ...

    Research Article last updated 07/20/2018 - 5:15pm.