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  1. The small population of PIG-A mutant cells in myelodysplastic syndromes do not arise from multipotent hematopoietic stem cells

    ... harbor clonal glycosylphosphatidylinositol-anchor deficient cells arising from a multipotent hematopoietic stem cell acquiring a PIG-A mutation . Many patients with aplastic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Identification of Gene Expression-Based Prognostic Markers in the Hematopoietic Stem Cells of Patients With Myelodysplastic Syndromes.

    ... we have used gene expression profiling (GEP) data on CD34+ cells from patients with MDS to determine the relationship between gene ... prognosis. PATIENTS AND METHODS: GEP data on CD34+ cells from 125 patients with MDS with a minimum 12-month follow-up since date ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Reduced ribosomal RNA expression and increased ribosomal DNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes

    ... (MDS) are clonal disorders of hematopoietic stem cells characterized by ineffective hematopoiesis . The DNA ... DNA methylation have been documented in bone marrow cells from MDS patients, the methylation signatures of specific gene promoters ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Stem and progenitor cells in myelodysplastic syndromes show aberrant stage specific expansion and harbor genetic and epigenetic alterations.

    ... Even though hematopoietic stem cell (HSC) dysfunction is presumed in MDS, the exact nature of ... relapse. This study demonstrates that stem and progenitor cells in MDS are characterized by stage specific expansions and contain ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Stem cell origin of myelodysplastic syndromes

    ... the involvement of multipotent, immature hematopoietic cells in the pathophysiology of this disease. Recent studies using ... that the most immature, self-renewing hematopoietic stem cells (HSC), as well as lineage-committed progenitor cells, are ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. How do PIG-A mutant paroxysmal nocturnal hemoglobinuria stem cells achieve clonal dominance?

    Journal Title:  Am J Hematol Primary Author:  Brodsky RA Author(s):  Brodsky ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Hematopoietic stem cell transplantation with umbilical cord multipotent stromal cell infusion for the treatment of aplastic anemia-a single-center experience.

    ... of co-transfusion of umbilical cord multipotent stromal cells (UC-MSC) and allogeneic hematopoietic stem cells in the treatment of heavily-transfused patients with severe ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria: long-term results of a retrospective study on behalf of the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

    ... is an acquired clonal disorder of the hemopoietic stem cells for which the only curative treatment is allogeneic hematopoietic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Excellent Outcome of Haploidentical Hematopoietic Stem Cell Transplantation in Children and Adolescents with Acquired Severe Aplastic Anemia

    ... anemia (SAA) who received haploidentical hematopoietic stem cell transplantation (HHCT) with in vitro T cell -depleted peripheral blood stem cells . Twelve patients with acquired SAA received a total of 15 HHCTs with ...

    Research Article last updated 07/20/2018 - 5:15pm.