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  1. Myelodysplastic syndromes in children: where are we today?

    ... and when detected make diagnosis easy. Hematopoietic stem cell transplant is the treatment of choice, while newer agents have shown ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... failure (N = 10); gross hemoglobinuria with isolated red cell anemia (N = 1); and jaundice , hepatitis, and isolated ... in 6 patients. Five patients underwent hematopoietic stem cell transplant (HSCT) of whom 3 patients are alive and disease-free. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Management of the refractory aplastic anemia patient: what are the options?

    ... in conjunction with centres of excellence. Hematopoietic stem cell transplant (HSCT) is indicated if refractory AA patients are fit for ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Oral Azacitidine (CC-486) for the Treatment of Myelodysplastic Syndromes and Acute Myeloid Leukemia

    ... therapy for patients with AML not eligible for stem cell transplant , and as maintenance therapy for patients with MDS or AML ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.

    ... may help select appropriate patients for allogeneic stem cell transplant . A variety of promising new agents are under investigation. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Comparison between Matched Related and Alternative Donors of Allogeneic Hematopoietic Stem Cells Transplanted into Adult Patients with Acquired Aplastic Anemia: Multivariate and Propensity Score-Matched Analysis.

    ... anemia (AA) who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) from matched related donors (MRDs), and those ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. 5-Azacytidine in myelodysplastic syndromes: a clinical practice guideline.

    ... ) who cannot proceed immediately to allogeneic stem cell transplant . 5-Aza is not recommended as first line therapy with MDS ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Outcome of Aplastic Anemia in adolescence. A survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation

    ... comparing (i) matched family donor hematopoietic stem cell transplantation performed as first line treatment with (ii) front-line immunosuppressive therapy not followed by subsequent transplant given for failure and with (iii) Hematopoietic Stem Cell ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Syngeneic transplantation in aplastic anemia: pretransplant conditioning and peripheral blood are associated with improved engraftment - an observational study on behalf of the Severe Aplastic Anemia and Pediatric Diseases Working Parties of the European

    ... and anti-thymocyte globulin as well as peripheral blood stem cells performed in later years. Ten year overall survival was 93% with ... than not and possibly to prefer peripheral blood as a stem cell source. Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. The diagnosis and treatment of aplastic anemia: a review

    ... pancytopenia . A trigger-related abnormal T cell response facilitated by some genetic predisposition has been ... (MSD) is not available for transplant. MSD hematopoietic stem cell transplantation (HSCT) is associated with cure in ~90 % of ...

    Research Article last updated 07/20/2018 - 5:15pm.