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  1. Haploidentical transplantation for pediatric patients with acquired severe aplastic anemia

    ... This result suggests that both newly diagnosed and refractory pediatric SAA patients benefit from haplo-HSCT, especially when ...

    Research Article last updated 01/24/2017 - 11:52am.

  2. Good riddance to the term "refractory anemia" in myelodysplastic syndromes

    ... The term " refractory anemia " was used in 1937 by Cornelius Parker Rhoads to ... the World Health Organization (WHO) proposed elimination of "refractory anemia" in a more general proposal for reclassification of myeloid ...

    Research Article last updated 11/02/2016 - 9:37am.

  3. MEDALIST Trial

    ... (ECOG) score of 0, 1, or 2 5.    Subjects who ar refractory /intolerant/ineligible to prior ESA treatment, defined as: Refractory to prior Erythropoiesis- stimulating agents(ESA) treatment: ...

    Clinical Trial last updated 02/22/2017 - 11:42am.

  4. A phase 2 trial of high dose lenalidomide in patients with relapsed/refractory higher-risk myelodysplastic syndromes and acute myeloid leukaemia with trilineage dysplasia

    ... Limited therapies exist for patients with refractory and relapsed (RR) higher-risk myelodysplastic syndromes ...

    Research Article last updated 11/02/2016 - 9:17am.

  5. Recent advances in the treatment of lower-risk non-del(5q) myelodysplastic syndromes (MDS)

    ... restricted to select patients. New strategies for ESA- refractory or relapsed patients include lenalidomide , alone or in ...

    Research Article last updated 12/09/2016 - 2:50pm.

  6. Left main crossover stenting in a patient with severe thrombocytopenia due to aplastic anemia

    ... 11 × 103/μL, hemoglobin 6.4 g/dL). Refractory heart failure persisted despite repeated conservative ...

    Research Article last updated 12/09/2016 - 2:08pm.

  7. Eltrombopag for the treatment of aplastic anemia: current perspectives

    ... patients. A significant proportion of patients are refractory to IST or relapse after IST. Various strategies have been ... as an encouraging and promising agent for patients with refractory AA. It has demonstrated efficacy in restoring trilineage ...

    Research Article last updated 11/01/2016 - 2:01pm.

  8. Are Myelodysplastic Syndromes Underdiagnosed in Poland? A Report by the Polish Adult Leukaemia Group

    ... age. The most frequently diagnosed MDS subtype was refractory cytopenia with multilineage dysplasia (RCMD), ...

    Research Article last updated 11/02/2016 - 10:17am.

  9. Hematopoietic Stem Cell Transplantation in Aplastic Anemia

    ... normal blood counts. Limitations of IST have included refractory disease, relapse and long-term risk of developing ... to excellent survival, the risk of events such as relapse, refractory disease, or clonal progression that we see with IST, was not seen ...

    Interview last updated 11/28/2016 - 2:58pm.

  10. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... in treating patients with relapsed or refractory acute myeloid leukemia. An immune cell is a type of blood cell ... enrolled are those patients with active relapsed or refractory CD123+ acute myeloid leukemia (AML) de novo , or ... disease (increased bone marrow blasts ) Refractory AML is defined as patients that have not achieved a CR after 2 ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.