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  1. T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell Transplantation in Patients With Hematologic Malignancies Relapsed or Refractory Despite Previous Allogeneic Transplant

    ... with hematologic malignancies that have relapsed or are refractory after prior allogeneic transplant. Toxicity will be evaluated by ...

    Clinical Trial last updated 05/03/2016 - 11:43am.

  2. Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-3032b in Hematological Malignancies

    ... Recommended Phase II Dose (RP2D) in subjects with refractory or relapsed Acute Myelogenous Leukemia (AML), Acute ... blast phase, or high risk MDS in Part 1-Dose Escalation and refractory or relapsed AML or high risk Myelodysplastic Syndrome (MDS) in ...

    Clinical Trial last updated 04/29/2016 - 1:50pm.

  3. Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

    ... Determine the incidence of relapse in patients with refractory anemia with excess blasts , refractory anemia with excess blasts in transformation, or acute myeloid ...

    Clinical Trial last updated 04/28/2016 - 8:49am.

  4. MEDALIST Trial

    ... (ECOG) score of 0, 1, or 2 5.    Subjects who ar refractory /intolerant/ineligible to prior ESA treatment, defined as: Refractory to prior Erythropoiesis- stimulating agents(ESA) treatment: ...

    Clinical Trial last updated 02/22/2017 - 11:42am.

  5. Allo HSCT Using RIC for Hematological Diseases

    ... remission. Chronic Myelogenous Leukemia excluding refractory blast crisis: To be eligible in first chronic phase (CP1) ... of an additional dose of 200 cGy of TBI CML in refractory blast crisis Intermediate or high grade NHL, mantle cell ...

    Clinical Trial last updated 05/02/2016 - 9:29am.

  6. Panobinostat With Fludarabine and Cytarabine for Treatment of Children With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... that are commonly used to treat pediatric patients with refractory or relapsed acute myeloid leukemia (AML) ... and cytarabine in pediatric patients with relapsed or refractory AML or MDS. SECONDARY OBJECTIVES: Characterize the ...

    Clinical Trial last updated 04/29/2016 - 10:11am.

  7. Drug: eltrombopag olamine Given PO Other Names: Promacta SB 497115 SB-497115 SB497115

    ... of GSK525762. Eligible subjects with relapsed refractory hematological malignancies will be enrolled in the OD and/or BID ... agent to be conducted in subjects with these relapsed and/or refractory hematological malignancies for which no standard therapies are ...

    Clinical Trial last updated 05/03/2016 - 12:03pm.

  8. A Biomarker-Directed Phase 2 Trial of SY-1425 in Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome

    ... the activity of SY-1425 in patients with relapsed/ refractory acute myeloid leukemia (AML) or high-risk myelodysplastic ...

    Clinical Trial last updated 08/24/2016 - 11:20am.

  9. Eltrombopag in aplastic anemia

    ... a potential therapy in case of stem cell depletion in refractory aplastic anemia. Eltrombopag was used for 43 aplastic anemia patients who were refractory to IST at National Institutes of Health (NIH), improving blood ...

    Research Review last updated 05/02/2016 - 9:13am.

  10. AML Therapy With Irradiated Allogeneic Cells

    ... Histologically proven non-M3 AML: Refractory /relapsed AML OR Initial diagnosis of AML in patient >= 60 ...

    Clinical Trial last updated 06/13/2016 - 3:14pm.