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  1. Management of the refractory aplastic anemia patient: what are the options?

    ... Refractory aplastic anemia (AA) is defined as lack of response to ... critical for AA patients, it is of paramount importance for refractory disease in view of the longer duration of pancytopenia and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Management of the refractory aplastic anemia patient: what are the options?

    ... Refractory aplastic anemia (AA) is defined as a lack of response to ... critical for AA patients, it is of paramount importance for refractory disease in view of the longer duration of pancytopenia and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Non-myeloablative peripheral blood haploidentical stem cell transplantation for refractory severe aplastic anemia

    ... approaches are urgently needed for patients with refractory severe aplastic anemia (SAA) who lack a matched sibling ... failed UD or cord blood transplant . Patients with refractory SAA are at risk of later clonal evolution to myelodysplastic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Lenalidomide in lower-risk myelodysplastic syndromes with karyotypes other than deletion 5q and refractory to erythropoiesis-stimulating agents

    ... without del(5q), but its efficacy in patients clearly refractory to erythropoiesis-stimulating agents (ESA) is not known. We ... consecutive lower-risk non-del(5q) MDS patients with anaemia refractory to ESA and treated with LEN in a compassionate programme, 20 of whom ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Activity of alemtuzumab monotherapy in treatment-naive, relapsed, and refractory severe acquired aplastic anemia

    ... from 2003-2010 in treatment-naïve, relapsed, and refractory SAA in three separate research protocols at the National ... Primary outcome was hematologic response at 6 months. For refractory disease, patients were randomized between rabbit ATG plus ... in SAA but best results are obtained in the relapsed and refractory settings. The trials were registered at www.clinicaltrials.gov ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Alternative donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection and graft versus host disease by immunoablative conditioning and graft manipulation

    ... H, Müller E, Schwinger W. Alternative donor HSCT in refractory acquired aplastic anemia - Prevention of graft rejection ... IST. Seven patients (median age at diagnosis, 11 yr) with refractory AAA without a MSD underwent HSCT from matched unrelated (n = 6) ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... One third of patients have disease that is refractory to immunosuppression, with persistent, severe cytopenia ... 2 study involving patients with aplastic anemia that was refractory to immunosuppression to determine whether the oral thrombopoietin ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Intravenous infusion of allogeneic mesenchymal stromal cells in refractory or relapsed aplastic anemia

    ... For patients with aplastic anemia (AA) who are refractory to anti-thymocyte globulin (ATG) and cyclosporine , a ... standard rabbit ATG and cyclosporine in nine patients with refractory or relapsed AA. RESULTS: After a median follow-up of 20 ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Low efficacy and high mortality associated with clofarabine treatment of relapsed/refractory acute myeloid leukemia and myelodysplastic syndromes

    ... nucleoside analog, has clinical activity in relapsed or refractory acute myelogenous leukemia (AML) and higher-risk ... for 84 patients treated with clofarabine for relapsed or refractory AML or MDS, either with clofarabine as monotherapy (n=19) or in ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Pediatric aplastic anemia and refractory cytopenia: A retrospective analysis assessing outcomes and histomorphologic predictors

    ... marrow failure syndrome and hypocellular refractory cytopenia of childhood (RCC). Historically, patients ...

    Research Article last updated 07/20/2018 - 5:15pm.