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  1. Causes

    ... of substance that helps certain proteins to stick to blood cells. Therefore, any blood cells created by this mutant bone marrow stem ... mutant PIG-A. The abnormal stem cells turn into mature red blood cells that have mutant PIG-A. These are called PNH red blood cells. ...

    Topic section last updated 07/30/2018 - 2:12pm.

  2. Increasing the effectiveness of hematopoiesis in myelodysplastic syndromes: erythropoiesis-stimulating agents and transforming growth factor-β superfamily inhibitors

    ... quality of life, as well as iron overload due to red blood cell transfusion support. To promote proliferation and differentiation of ...

    Research Article last updated 10/02/2017 - 10:10am.

  3. Lenalidomide: Myelodysplastic syndromes with del(5q) and beyond

    ... sensitive to lenalidomide for the treatment of red blood cell transfusion -dependent anemia . Although lenalidomide has ...

    Research Article last updated 10/02/2017 - 9:54am.

  4. Red Blood Cell Transfusion Dependency and Hyperferritinemia Are Associated with Impaired Survival in Patients Diagnosed with Myelodysplastic Syndromes: Results from the First Polish MDS-PALG Registry

    ... analysis of the relationship of SF concentration with red blood cell transfusion dependency, survival and transformation to acute ...

    Research Article last updated 10/06/2016 - 1:01pm.

  5. Early treatment initiation in lower-risk myelodysplastic syndromes produces an earlier and higher rate of transfusion independence

    ... resulting in refractory cytopenias. Red blood cell (RBC) transfusions can improve anemia ; however, prolonged ...

    Research Article last updated 09/13/2017 - 8:58am.

  6. What the Future May Hold

    ... Link:  Transplantation of Young Blood Vessel Cells Boosts Function of Aging Stem Cells ... aged bone marrow -derived blood vessels (depicted in red and green with blue nuclei). The excess buildup of reactive oxygen species ...

    Article last updated 10/30/2017 - 7:32am.

  7. Standardized High-Sensitivity Flow Cytometry Testing for Paroxysmal Nocturnal Hemoglobinuria in Children with Acquired Bone Marrow Failure Disorders: A Single Center U.S. Study

    ... (PNH) is a rare, acquired hematopoietic stem cell disorder that has not been well documented in children, particularly those ... and CD235a/CD59 panels were used for white blood cell and red blood cell testing, respectively. RESULTS: Thirty seven ...

    Research Article last updated 06/26/2017 - 9:22am.

  8. Research in making blood stem cells in the lab advances

    ... Approaching a decades-old goal: Making blood stem cells from patients' own cells ... bone marrow and blood circulation. These included red blood cell precursors, myeloid cells (precursors of monocytes, ...

    Article last updated 05/18/2017 - 7:18am.

  9. Marrow protein may be key to SCT success

    ... hematopoetic stem cells , the precursors to every blood cell type. These cells spring into action following bone marrow ... Tatyana Grinenko of TU-Dresden; Torsten Tonn of the German Red Cross Blood Donation Service in Dresden; and Marianna Di Scala and Andrés ...

    Article last updated 08/29/2017 - 11:18am.

  10. Isabel Mérida, PhD

    ... in which the bone marrow gradually stops producing red and white blood cells and platelets. As a result, people with aplastic anemia feel tired, ...

    Grant Recipient last updated 07/05/2018 - 11:17am.