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  1. Prognostic value of self-reported fatigue on overall survival in patients with myelodysplastic syndromes: a multicentre, prospective, observational, cohort study

    ... dependency (defined as having received at least one red blood cell transfusion every 8 weeks over a period of 4 months), Eastern ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Paroxysmal nocturnal hemoglobinuria in pediatric patients.

    ... Journal Title:  Pediatr Blood Cancer Primary Author:  ... failure (N = 10); gross hemoglobinuria with isolated red cell anemia (N = 1); and jaundice , hepatitis, and ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Clinical roundtable monograph: Paroxysmal nocturnal hemoglobinuria: a case-based discussion.

    ... glycan anchor (PIG-A) in a multipotent hematopoietic stem cell (HSC), with clonal expansion of the mutated HSC. The mutation causes a ... GPI-linked proteins, are absent from the cell surface of red cells, granulocytes, monocytes, and platelets, resulting in ... hemolysis and other complications. Lysis of red blood cells is the most obvious manifestation, but as other cell lineages are ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Current concepts in the pathophysiology and treatment of aplastic anemia

    ... viewed in isolation as an odd, rare, and invariably fatal blood disease, aplastic anemia is now of substantial interest for its ... of patients. Once relegated to a few presentations in the red cell and anemia sessions of the ASH, the Society now sponsors multiple ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... The presence of these mutations leads to production of blood cells with decreased GPI-anchored cell surface proteins, making red blood cells (RBC) derived from the clone more sensitive to ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.

    ... discuss methods for assessing PNH populations in both white blood cells and red blood cells and the relative advantages of measuring each. We present ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Optimizing therapy for iron overload in the myelodysplastic syndromes: recent developments.

    ... (AML). Most MDS patients eventually require transfusion of red blood cells for anaemia, placing them at risk of transfusional iron ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug

    ... Journal Title:  Blood Primary Author:  ... eventually had significant increases in neutrophil , red cell and platelet lineages. Five patients with robust ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Therapy for aplastic anemia

    ... in the unrelated donor registry, including cord blood. He is red cell- and platelet transfusion -dependent. He has been recommended ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Prolonged survival with improved tolerability in higher-risk myelodysplastic syndromes: azacitidine compared with low dose ara-C.

    ... more and longer haematological responses and increased red blood cell transfusion independence . Azacitidine prolonged overall ...

    Research Article last updated 07/20/2018 - 5:14pm.