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  1. Interviews with the Experts Managing MDS With Supportive Care and Active Treatment

    ... to giving a specific drug or agent that treats the disease. Blood transfusions are the backbone of supportive care for patients with MDS, ... group of agents used is growth factors.  This includes red blood cell growth factors like erythropoietin (Procrit®) or ...

    Interview last updated 09/22/2014 - 12:25pm.

  2. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... there is a lack of certain proteins on the surface of the red blood cells. These proteins (such as CD55 and CD59) normally prevent the red ...

    Research Review last updated 05/02/2016 - 9:26am.

  3. The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure.

    ... Research Review: Low blood counts can be attributed to several different medical conditions.  ... failure syndromes, myeloproliferative neoplasms, and pure red cell aplasia. Single-nucleotide polymorphism array karyotyping ...

    Research Review last updated 05/02/2016 - 9:18am.

  4. A Rare Genetic Polymorphism in C5 Confers Poor Response to the Anti-C5 Monoclonal Antibody Eculizumab by Nine Japanese Patients with PNH

    ... and inactivates the C5 complement protein and protects the red cell from the pore forming on its surface. This prevents breakdown of red blood cells that occurs in the circulation and turns very dark urine clear ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. Soliris

    ... the need for transfusions Reduce the breaking apart of red blood cells ( hemolysis ) over both the short and the long term ...

    Page last updated 06/29/2015 - 9:07am.

  6. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... for different reasons. In classic PNH, there is breakdown of red cells and the reticulocyte count is high, but with aplastic anemia, ... eculizumab (Soliris®) or anticoagulants to prevent blood clots. Aplastic anemia patients need immunosuppression, generally being ...

    Interview last updated 04/15/2015 - 9:39am.

  7. Fludarabine Phosphate, Cyclophosphamide, Total-Body Irradiation, and Donor Bone Marrow Transplant Followed by Donor Natural Killer Cell Therapy, Mycophenolate Mofetil, and Tacrolimus in Treating Patients With Hematologic Cancer

    ... they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Giving an infusion of the ...

    Clinical Trial last updated 04/29/2016 - 12:48pm.

  8. PNH: Causes

    ... PIG-A. The abnormal stem cells turn into mature red blood cells that have mutant PIG-A. These are called PNH red blood cells. ...

    Page last updated 06/29/2015 - 8:44am.

  9. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... dependence* ANC <1000 x 109/L Hgb <8 gm/dl or red cell transfusion dependence* Myelodysplastic Syndrome (MDS) ... filgrastim neupogen Biological: Peripheral blood stem cell The source of stem cells for all patients will be ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  10. What are the treatments for PNH?

    ... your doctor might decide to do nothing but monitor your blood counts if they aren't too low and your symptoms aren't too bad. ... system. This reduces hemolysis , the destruction of red blood cells. Bone marrow/stem cell transplantation (BMT/SCT):  A ...

    FAQ last updated 03/15/2016 - 11:32pm.