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  1. ASH 2012 - Reviewing MDS Progress from Research and Clinical Perspectives

    ... (Procrit®) or darbepoetin (Aranesp®) work for low red blood cell counts. Romiplostin can be considered a platelet growth ...

    Interview last updated 02/07/2013 - 1:28pm.

  2. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... on later. Eventually a pore is formed in the surface of the red cell from patients with PNH which causes the cell to break open. Eculizumab ... might prevent both types of hemolysis (breakdown in the blood vessels and extravascular hemolysis) and might be more effective than ...

    Research Review last updated 05/02/2016 - 9:25am.

  3. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... (scarring in the marrow), a chronically high white blood cell or platelet count, especially if they have the JAK2 ... for different reasons. In classic PNH, there is breakdown of red cells and the reticulocyte count is high, but with aplastic anemia, ...

    Interview last updated 05/14/2015 - 1:53pm.

  4. Eculizumab

    ... the need for transfusions Reduce the breaking apart of red blood cells ( hemolysis ) over both the short and the long term Reduce ...

    Topic section last updated 03/29/2016 - 7:20pm.

  5. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood cells to be made. Platelets are particles which circulate in the ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  6. Patient Education Materials

    ... patient guide on myelodysplastic syndromes (MDS) begins with blood basics, MDS classifications, and then specifics on symptoms, tests, ... Bone Marrow Failure Disease: Resulting from successive red blood cell transfusions that some patients may receive, excess iron in ...

    Page last updated 11/06/2013 - 4:28pm.

  7. Heather Putney’s Trials (and Travels) with Aplastic Anemia

    ... to the gynecologist and a painless bruise led to a complete blood count draw, which showed markedly low platelets and hematocrit . ... Within two months, I was transfusion dependent for both red blood cells and platelets. In June, I was admitted for an allogenic bone ...

    Patient Chronicle last updated 08/15/2016 - 8:42am.

  8. MDS: Diagnosis

    ... To understand what is causing your symptoms and low blood counts, your doctor will take a detailed medical history. Your doctor may ... type in your blood sample. If the CBC shows a low number of red blood cells, white blood cells, or platelets, your doctor may look at the ...

    Page last updated 01/20/2015 - 4:42pm.

  9. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood cells to be made. Platelets are particles which circulate in the ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  10. PNH 101: Understanding Diagnosis and Treatment

    ... PNH is a bone marrow failure disease that causes red blood cells to break apart. Doctors call this process hemolysis . This ...

    LMS Item last updated 06/10/2016 - 1:24pm.