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  1. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... on later. Eventually a pore is formed in the surface of the red cell from patients with PNH which causes the cell to break open. Eculizumab ... might prevent both types of hemolysis (breakdown in the blood vessels and extravascular hemolysis) and might be more effective than ...

    Research Review last updated 05/02/2016 - 9:25am.

  2. Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

    ... compared to filgrastim (G-CSF) mobilized peripheral blood stem cell (PBSC) transplants, BM allografts have lower CD34+ progenitor ... 2) Severe aplastic anemia (SAA) or pure red cell aplasia (PRCA [acquired or congenital]) associated with transfusion ...

    Clinical Trial last updated 04/28/2016 - 2:40pm.

  3. What are low blood counts?

    When you have a low blood count, this means your bone marrow is not making enough of ... cell in your blood sample. If the CBC shows a low number of red blood cells, white blood cells, or platelets, your doctor may look at the ...

    FAQ last updated 04/28/2016 - 4:47pm.

  4. Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Hematologic Malignancies Undergoing Donor Peripheral Blood Stem Cell Transplant

    ... with hematologic malignancies undergoing donor peripheral blood stem cell (PBSC) transplant. Giving chemotherapy and total-body ... may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. Sometimes the transplanted ...

    Clinical Trial last updated 04/28/2016 - 12:07pm.

  5. A Study of Luspatercept (ACE-536) to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MEDALIST)

    ... IN SUBJECTS WITH RING SIDEROBLASTS WHO REQUIRE RED BLOOD CELL TRANFUSIONS Status:  ...

    Clinical Trial last updated 04/21/2016 - 1:16pm.

  6. Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant (ICT-HCT)

    ... of cancer cells in the bone marrow , including normal blood-forming cells ( stem cells ) and cancer cells, and may prevent ... they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. ...

    Clinical Trial last updated 04/27/2016 - 9:41am.

  7. Randomized Trial of Pegylated Interferon Alfa-2a Versus Hydroxyurea in Polycythemia Vera (PV) and Essential Thrombocythemia (ET)

    ... Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood cells to be made. Platelets are particles which circulate in the ...

    Clinical Trial last updated 05/02/2016 - 2:31pm.

  8. Types

    ... you have moderate aplastic anemia:  You may have low blood cells counts, but not as low as with severe aplastic anemia.  You ... microliter. Your reticulocyte (young red blood cell ) count is less than 20,000 per microliter.  Your ...

    Topic section last updated 04/19/2016 - 3:36pm.

  9. Pegylated Interferon Alfa-2a Salvage Therapy in High Risk Polycythemia Vera (PV) or Essential Thrombocythemia (ET)

    ... Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and PV causes too many platelets and red blood cells to be made. Platelets are particles which circulate in the ...

    Clinical Trial last updated 04/29/2016 - 9:59am.

  10. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... there is a lack of certain proteins on the surface of the red blood cells. These proteins (such as CD55 and CD59) normally prevent the red ...

    Research Review last updated 05/02/2016 - 9:26am.