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  1. Development and validation of a model to predict platelet response to romiplostim in patients with lower-risk myelodysplastic syndromes

    ... between endogenous thrombopoietin (THPO) levels and platelet response to romiplostim is unknown. Variables including baseline endogenous THPO levels, transfusion needs, and platelet response were analysed in a randomized trial of 250 thrombocytopenic, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Decreased plasma cytokines associate with low platelet counts in aplastic anemia and immune thrombocytopenic purpura

    ... anemia (AA) patients and to be correlated with the platelet count. Objectives: To study the association of CD40L, CXCL5, ... proteins were significantly greater in patients with higher platelet counts than in those with lower platelet counts. In a murine ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. ASCO Updates Platelet Transfusion Guideline Prophylaxis unnecessary for adults undergoing HSCT

    ... stem-cell transplants (HSCT) may safely delay platelet infusion until the first sign of bleeding, as opposed to ... infusion, according to an updated guideline for platelet transfusion in patients with cancer. The recommendation, which ...

    Research Article last updated 12/06/2017 - 11:23am.

  4. Platelet count doubling after the first cycle of azacitidine therapy predicts eventual response and survival in patients with myelodysplastic syndromes and oligoblastic acute myeloid leukaemia but does not add to prognostic utility of the revised IPSS

    ... syndromes (MDS) are not defined. Doubling of platelet count at start of second cycle of azacitidine therapy compared to ... follow-up. We found a significant association between platelet count doubling after first cycle of azacitidine therapy and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Relationship of different platelet response criteria and patient outcomes in a romiplostim myelodysplastic syndromes trial

    Journal Title:  Leukemia Primary Author:  Platzbecker U Author(s):  Platzbeck...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Under-recognition of Platelet dysfunction in Myelodysplastic Syndromes: are we only seeing the tip of the iceberg?

    Journal Title:  Leuk Lymphoma Primary Author:  Burbury KL Author(s):  Burbury...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Phase II clinical study of erlotinib for treatment of myelodysplastic syndromes

    ... patients with transfusion-dependent anemia or platelet counts <50 × 109 /L or a significant clinical hemorrhage requiring platelet transfusion or ANC <1 × 109 /L were eligible, with most of our ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Altered immunophenotypic features of peripheral blood platelets in myelodysplastic syndromes.

    ... cytometry for the detection of megakaryocytic and platelet dysplasia has not yet been investigated. The aim of this pilot ... by flow cytometry the diagnostic and prognostic value of platelet dysplasia in myelodysplastic syndromes. DESIGN AND METHODS: We ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Symptoms

    ... Low Platelet Counts A low platelet count is called thrombocytopenia . If you have a low ...

    Topic section last updated 09/14/2018 - 2:46pm.

  10. Pathophysiology and management of thrombocytopenia in bone marrow failure: possible clinical applications of TPO receptor agonists in aplastic anemia and myelodysplastic syndromes.

    ... this approach. Patients may require frequent blood and platelet transfusion support which is expensive and inconvenient. ... complications still occur despite prophylactic platelet transfusion. Thrombopoietin (TPO) mimetics, such as romiplostim and ...

    Research Article last updated 07/20/2018 - 5:15pm.