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  1. Prediction of adverse events during Intensive Induction chemotherapy for acute myeloid leukemia or high-grade myelodysplastic syndromes

    ... (n=30). Among the entire cohort, baseline grade 4 neutropenia (i.e. absolute neutrophil count <500 cells/µL) was ... patients who received "7+3"-like induction, baseline grade 4 neutropenia remained associated with documented infection (P<0.0001) and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Lenalidomide for del(5q) and Non-del(5q) Myelodysplastic Syndromes

    ... independence is 2 years, mainly at the expense of neutropenia and thrombocytopenia in the first courses of therapy. ... of duration of response, and 50% incidence of grade 3 and 4 neutropenia and thrombocytopenia compared to del(5q) patients. Recent data ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Infections in myelodysplastic syndromes: a review

    ... are associated with a risk of severe infections. While neutropenia is likely the main predisposing factor, several other immune ... in myelodysplastic syndromes but can transiently worsen neutropenia, may increase the risk of infection and their severity in this ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Infections in patients with aplastic anemia.

    ... difference in the infections that they incur. Prolonged neutropenia is one of the largest risk factors for the development of ... with the invasive mycoses and bacteria. Recovery from neutropenia is directly related to survival, and supportive care plays ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. GATA2 deficiency-associated bone marrow disorder differs from idiopathic aplastic anemia

    ... been reported in a minority of patients with congenital neutropenia and aplastic anemia (AA). The bone marrow (BM) ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Immunosuppressive therapy for transplant-ineligible aplastic anemia patients

    ... patients are at risk of infection and hemorrhage due to neutropenia and thrombocytopenia and suffer from symptoms of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. An exploratory phase 2 study of investigational Aurora A kinase inhibitor alisertib (MLN8237) in acute myelogenous leukemia and myelodysplastic syndromes

    ... events >30% included diarrhea, fatigue, nausea, febrile neutropenia , and stomatitis. Results suggest modest activity in AML, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... was considerable, mainly due to prolonged absolute neutropenia , which occurred regardless of pre-therapy blood counts and ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Effectiveness and safety of different azacitidine dosage regimens in patients with myelodysplastic syndromes or acute myeloid leukemia

    ... (OS) durations were 13.2, 19.1, and 14.9 months. Neutropenia was the most common grade 3-4 adverse event. These results ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Use of azacitidine for myelodysplastic syndromes: controversial issues and practical recommendations.

    ... with lower-risk MDS who have thrombocytopenia or neutropenia or have anemia that is unresponsive to other therapies. ...

    Research Article last updated 07/20/2018 - 5:15pm.