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  1. Announcing AAMDSIF 2016 Research Awards

    ... (PNH). In this condition, due to a gene mutation , some bone marrow cells and their progeny in the blood lack an ... swallowing, or develop blood clots. The cause of the gene mutation is unknown. Some patients with other conditions, such as aplastic ...

    Article last updated 06/09/2016 - 12:45pm.

  2. Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents

    ... to therapy or acquired aplastic anemia . Mutation carriers were older at diagnosis and more likely to present with ...

    Research Article last updated 04/29/2016 - 10:24am.

  3. Effect of lenalidomide treatment on clonal architecture of myelodysplastic syndromes without 5q deletion

    ... was also determined in 5 cases. Four genes had a mutation frequency over 10%: SF3B1 (74.5%), TET2 (45.7%), DNMT3A (20.2%) ...

    Research Article last updated 04/29/2016 - 11:33am.

  4. Personalized medicine for MDS

    ... example, a younger patient with a negative prognostic mutation may be considered for a more intensive treatment, such as ... About 20% of patients with del (5q) have a concurrent TP53 mutation which suggests more aggressive disease and should be treated ...

    Research Review last updated 05/02/2016 - 9:44am.

  5. Advances in the molecular pathology of MDS

    ... clinical practice. The frequent finding of more than one mutation in patients confirms that MDS are a group of heterogeneous ...

    Research Review last updated 05/02/2016 - 9:44am.

  6. Myelodysplastic syndromes: Contemporary review and how we treat

    ... MDS. Going forward, we believe it is time to incorporate mutation information in clinically derived prognostic models in MDS and ...

    Research Article last updated 04/29/2016 - 1:05pm.

  7. Myelofibrosis (MF)

    ... to myelofibrosis over time The presence of the JAK2 mutation Exposure to certain industrial chemicals, such as toluene and ...

    Topic section last updated 07/07/2016 - 3:16pm.

  8. Clinical and Genetic Heterogeneity of Telomere Diseases

    ... for in all patients. Interestingly, a telomere gene mutation may be found in patients who seem to have a primary immune defect, ... of the genetic abnormality suggesting that finding a genetic mutation should not preclude such treatment. ...

    Research Review last updated 05/02/2016 - 9:24am.

  9. PNH: Secondary Mutations and Thrombosis

    ... a brief overview of the common PIG-A gene mutation that occurs in PNH patients and how different patients have ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  10. Donor Lymphocyte Infusion (DLI) of T-cells Genetically Modified With iCasp9 Suicide Gene

    ... intermediate or high cytogenetic risk factors or flt3 mutation . Patients with relapsed disease. Patients with primary induction ...

    Clinical Trial last updated 06/06/2016 - 12:41pm.