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  1. p53 protein expression independently predicts outcome in patients with lower-risk myelodysplastic syndromes with del(5q)

    ... cells with strong p53 expression confirmed TP53 mutation , whereas cells with moderate expression were predominantly of ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Key clinical observations after 5-azacytidine and decitabine treatment of myelodysplastic syndromes suggest practical solutions for better outcomes

    ... that there can be no therapeutic benefit, regardless of mutation or cytogenetic subtype, if DNA methyltransferase is not depleted ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Validation of a Prognostic Model and the Impact of Mutations in Patients With Lower-Risk Myelodysplastic Syndromes

    ... 1.85 to 4.52). CONCLUSION Combining the LR-PSS and EZH2 mutation status identifies 29% of patients with lower-risk MDS with a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Epigenetic regulation in myelodysplastic syndromes: implications for therapy.

    ... and high-risk MDS. Methylation profiles and gene mutation predictors provide promising areas of development for monitoring ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes

    ... which might be influenced by the presence of SRSF2 mutation . Bone Marrow ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... PIG-A Gene Mutation PNH occurs because of a genetic change ( mutation ) in the PIG-A gene of a single stem cell in your bone marrow ...

    Page last updated 07/20/2018 - 5:15pm.

  7. Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome

    ... Article Link:  Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic ... Background DNMT3A  gene mutation has been associated with poor prognosis in acute myeloid leukemia, ...

    Article last updated 04/03/2018 - 1:32pm.

  8. A Remarkable Response in a Clinical Trial

    ... had failed. After another bone marrow biopsy, a genetic mutation (the IDH1 gene) was identified. Then, the shocking statement was ... Leigh Clark, what my issues were and my specific genetic mutation. She immediately wrote me back:  "Hang on and give me 24 hours". In ...

    Patient Chronicle last updated 04/26/2018 - 12:46pm.

  9. A Phase 1b/2 Study to Evaluate the Safety and Efficacy of APR-246 in Combination with Azacitidine for the Treatment of TP53 Mutant Myeloid Neoplasms

    ... (WHO) criteria. Documentation of a TP53 gene mutation by NGS based on central or local evaluation. For TP53 mutant ...

    Clinical Trial last updated 04/21/2018 - 6:04pm.

  10. MDS Rounds: An AAMDSIF Visiting Faculty Program

    ... relationship between clinical symptoms and genetic mutation profiles. •    During the past decade, extensive research ...

    Page last updated 01/24/2018 - 2:05pm.