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  1. The molecular pathogenesis of the myelodysplastic syndromes

    ... a pathway not previously known as a target for mutation , in the MDS pathogenesis. Several regulators of signal ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Investigation of 305 patients with myelodysplastic syndromes and 20q deletion for associated cytogenetic and molecular genetic lesions and their prognostic impact

    ... by fluorescence in situ hybridization , molecular mutation screening, and array comparative genomic hybridization (aCGH). By ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... disease of hematopoietic stem cells due to a mutation in the PIG-A gene leading to a deficiency of GPI-anchored ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... marrow failure . PNH is due to a somatic, acquired mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... marrow failure . PNH is due to a somatic, acquired mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Guidelines for the diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria and related disorders by flow cytometry.

    ... stem cell disorder characterized by a somatic mutation in the PIGA gene, leading to a deficiency of proteins linked to ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... hematopoietic stem cell (HSC) that acquires a somatic mutation in a gene called phosphatidylinositol glycan anchor biosynthesis, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Somatic mutations and epigenetic abnormalities in myelodysplastic syndromes

    ... prognosis, while some gene mutations (mainly TET2 mutation ), may be associated to better response to hypomethylating agents. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Emerging roles of the spliceosomal machinery in myelodysplastic syndromes and other hematological disorders

    ... to intense investigation. For SF3b1, a gain of function mutation may offer the promise of new targeted therapies for diseases that ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Prognostic value of telomere attrition in patients with aplastic anemia.

    ... from patients with critically short telomeres and/or mutation in telomerase genes. The possibility of modulating telomere ...

    Research Article last updated 07/20/2018 - 5:15pm.