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  1. Myelofibrosis (MF)

    ... to myelofibrosis over time The presence of the JAK2 mutation Exposure to certain industrial chemicals, such as toluene and ...

    Topic section last updated 07/07/2016 - 3:16pm.

  2. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... t(3;3) t(6;9) t(9;22) Normal karyotype with FLT3-ITD mutation Chronic myelogenous leukemia (accelerated, blast or ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  3. Intra-Osseous Co-Transplant of UCB and hMSC

    ... markers (e.g. fms-related tyrosine kinase 3 [Flt 3] mutation , 11q23, del 5, del 7, complex cytogenetics) Second complete ...

    Clinical Trial last updated 05/02/2016 - 11:15am.

  4. Dr. Vivienne Rebel reports on a study of the relationship between gene mutations and overall survival after stem cell transplant

    ... survival after transplantation for patients with this mutation was only 4.6 months and none lived much beyond 4 years.  Thus, it ... has minimal, if any, benefits for MDS patients with a TP53 mutation.  The authors conclude that if a blood-stem cell transplantation is ...

    Research Review last updated 05/02/2016 - 9:16am.

  5. Identification of genetic abnormalities in MDS patients that may lead to a better diagnosis and treatment strategy of MDS patients

    ... (nearly twice as high) in the group of patients with a mutation in the TET2 gene in their blood cells compared to the group who did not have this mutation.  Mutations that can predict therapeutic outcome are of importance ...

    Research Review last updated 05/02/2016 - 9:23am.

  6. Daria Babushok, MD, PhD

    ... progeny of a single cell that initially acquired a given mutation . This phenomenon, where a large fraction of blood cells originate ...

    Bio last updated 03/11/2016 - 1:41pm.

  7. Zhe Yang, PhD

    ... in MDS. The exciting new discovery of frequent Tet2 mutation in a wide range of myeloid malignancies including ...

    Grant Recipient last updated 12/06/2013 - 4:25pm.

  8. Mridul Mukherji, DPhil

    ... (MDS). Results from recent studies have established that mutation in the TET2 tumor suppressor gene is one of the fundamental causes ...

    Grant Recipient last updated 10/01/2012 - 10:46am.

  9. Eric Padron, M.D.

    ... Other work Dr. Padron is pursuing involves the SRSF2 mutation that can occur in MDS and may be related to progression to other ...

    Bio last updated 03/11/2016 - 1:41pm.

  10. Rosannah Cameron, PhD.

    ... blood-forming stem cells, we study zebrafish that have a mutation in a spliceosomal gene commonly mutated in MDS (sf3b1). The aim of ...

    Bio last updated 03/11/2016 - 1:41pm.