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  1. Very Short Telomeres of Peripheral Blood Leukocytes Precede Clinical Progression to Myelodysplasia with Monosomy 7 in Aplastic Anemia Patients

    ... Society of Hematology (ASH) Annual Meeting, December 7-10 in Atlanta, Georgia. The full abstracts may be viewed on the ASH Annual ...

    Research Review last updated 05/02/2016 - 9:24am.

  2. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... total nucleated cell (TNC) dose must be a minimum of 4.0 x10^7/kg recipient weight. For double cord transplants, each unit must have a ... syndrome (pre-MDS) or MDS on marrow examination (e.g. Monosomy 7 ). Presence of anti-donor HLA antibodies (positive ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  3. Clonal Evolution in Aplastic Anemia is Driven by Chromosomal Instability Rather than Mutations in Myeloid Malignancy Candidate Gene

    ... Society of Hematology (ASH) Annual Meeting, December 7-10 in New Orleans, Louisiana.The full abstract may be reviewed on the ASH ... with aplastic anemia. Aplastic anemia had progressed to monosomy 7 in 13 of these patients. Monosomy 7, a type of MDS, involves the ...

    Research Review last updated 05/02/2016 - 9:20am.

  4. The Challenging World of Cytopenias: Distinguishing Myelodysplastic Syndromes From Other Disorders of Marrow Failure.

    ... other bone marrow failure disorders, such as del (5q), monosomy 7 , inversion 3, del (Y), 20q, and trisomy 8 among others. The ...

    Research Review last updated 05/02/2016 - 9:18am.

  5. Immune System Suppression and Bone Marrow Failure

    ... examined patients whose aplastic anemia progressed to monosomy 7 (meaning that they had only one copy, instead of the usual two copies, of ...

    Research Review last updated 05/02/2016 - 9:15am.

  6. Eltrombopag With Standard Immunosuppression for Severe Aplastic Anemia

    ... will develop an abnormal karyotype in follow-up, with monosomy 7 being most common, which portends progression to myelodysplasia and ...

    Clinical Trial last updated 04/25/2016 - 2:47pm.

  7. Transplantation Update

    ... we consider complex,  high-risk cytogenetics ( monosomy 7 and others) which was the major cause of failure due to relapse in ...

    Interview last updated 05/14/2015 - 2:42pm.

  8. Pediatric MDS

    ... We have had a few families we have treated with familial monosomy 7 -related MDS, and that doesn’t occur on the adult side. Finally, some of ...

    Interview last updated 10/24/2012 - 1:31pm.

  9. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... Myelodysplastic Syndrome (treatment-related, monosomy 7 or complex cytogenetics, IPSS score of 1.5 or greater, Chronic ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  10. North American Pediatric Aplastic Anemia Consortium Symposium

    ... in the absence of an MDS defining clone , such as monosomy 7 , these overlapping morphologies can make for imprecise diagnoses. ...

    Page last updated 10/31/2013 - 4:06pm.