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  1. Outcome of children with severe acquired aplastic anemia treated with rabbit antithymocyte globulin and cyclosporine A

    ... after immunosuppressive therapy was 8.3% (95% CI: 0.001%-53.7%) at five years with both clonal evolutions in non -responders who acquired monosomy 7 karyotype. The overall survival at five years was 73.6% (95% ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Pediatric myelodysplastic syndromes: they do exist!

    ... associated with hypocellular bone marrow and monosomy 7 . Refractory cytopenia is more typical than refractory anemia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Horse antithymocyte globulin as salvage therapy after rabbit antithymocyte globulin for severe aplastic anemia

    ... of relapse, and in nonresponders 2 patients evolved to monosomy 7 . The overall survival for the cohort at 3 years was 68% (95% CI, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Clonal evolution in aplastic anemia

    ... of diagnostic chromosomal abnormalities (mostly monosomy 7 ) is of great clinical importance. Newer whole-genome scanning ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Allogeneic hematopoetic stem cell transplantation in pediatric myelodysplastic syndromes: Improved outcomes for de novo disease.

    ... patients had a documented cytogenetic abnormality, and monosomy 7 /7q- was seen in 12 patients (52%). Fourteen of 23 patients received a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Hematopoietic stem cell transplantation in children and young adults with secondary myelodysplastic syndrome and acute myeloid leukemia following aplastic anemia

    ... At a median age of 13.1 years (range, 4.4 to 26.7 years), patients underwent HSCT with bone marrow (n = 6) or ... family donors (n = 2), or unrelated donors (n = 13). Monosomy 7 was detected in 13 patients. The preparative regimen consisted ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. "Moderate" dose cyclophosphamide for severe aplastic anemia has significant toxicity and does not prevent relapse and clonal evolution

    ... abnormalities were observed in 4 patients, including monosomy 7 . Although cyclophosphamide has activity in SAA, its toxicity is not ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... higher in patients in the first quartile (24.5%; 95% CI, 8.7%-37.5%) than in quartiles 2 through 4 (8.4%; 95% CI, 3.2%-13.3%; P = .009), and evolution to monosomy 7 or complex cytogenetics was more common in the first ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Optimizing Cord Blood and Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502) (CHAMP)

    ... total nucleated cell (TNC) dose must be a minimum of 4.0 x10^7/kg recipient weight. For double cord transplants, each unit must have a ... syndrome (pre-MDS) or MDS on marrow examination (e.g. Monosomy 7 ). Presence of anti-donor HLA antibodies (positive ...

    Clinical Trial last updated 12/19/2017 - 7:55am.

  10. Prevalence, clinical characteristics and prognosis of GATA2-related myelodysplastic syndromes (MDS) in children and adolescents

    ... Germline GATA2 mutations accounted for 15% of advanced and 7% of all primary MDS cases, but were absent in children with MDS secondary to ... were older at diagnosis and more likely to present with monosomy 7 and advanced disease as compared to wildtype cases. For ...

    Research Article last updated 04/29/2016 - 10:24am.