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  1. Immunotherapies for the treatment of AML

    ... Description: Gemtuzumab ozogamicin is a monoclonal antibody drug for the treatment of acute myeloid leukemia (AML). This drug ...

    Article last updated 08/14/2018 - 8:32am.

  2. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... inhibitor eculizumab , a humanized anti-C5 monoclonal antibody , has been proven safe and effective for the treatment of PNH ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... inhibitor eculizumab , a humanized anti-C5 monoclonal antibody , has been proven safe and effective for the treatment of PNH ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Eculizumab in Pregnant Patients with Paroxysmal Nocturnal Hemoglobinuria

    ... BACKGROUND: Eculizumab , a humanized monoclonal antibody against complement protein C5 that inhibits terminal complement ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Paroxysmal nocturnal hemoglobinuria

    ... syndrome 2. Eculizumab , first-in-class monoclonal antibody that inhibits terminal complement, is the treatment of choice for ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Assessing complement blockade in patients with paroxysmal nocturnal hemoglobinuria receiving eculizumab

    ... controlled with eculizumab , a humanized monoclonal antibody that binds complement protein C5. The residual functional ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Allogeneic stem cell transplantation using alemtuzumab-containing regimens in severe aplastic anemia.

    ... Alemtuzumab , a humanized anti-CD52, IgG1 monoclonal antibody , is used to reduce graft-versus- host disease (GVHD) and aid ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... clinical hallmark of PNH. In the last decade the anti-C5 monoclonal antibody has been proven effective for the treatment of PNH, resulting in a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Cotransplantation of allogeneic mesenchymal and hematopoietic stem cells in children with aplastic anemia

    ... and mycophenolate mofetil, with or without anti-CD25 monoclonal antibody . The grafts were granulocyte colony-stimulating ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... reported in children. Eculizumab , a humanized monoclonal antibody targeting and preventing cleavage of the terminal complement ...

    Research Article last updated 07/20/2018 - 5:14pm.