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  1. Optimizing therapy for iron overload in the myelodysplastic syndromes: recent developments.

    ... cells for anaemia, placing them at risk of transfusional iron overload . In β-thalassaemia major, transfusional iron overload leads to organ dysfunction and death; however, with iron chelation therapy , organ function is improved, and survival improved to ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Iron status and treatment modalities in transfusion-dependent patients with myelodysplastic syndromes.

    ... Transfusion dependency and iron overload are common among patients with myelodysplastic syndromes ... progression and shorter survival. Guidelines recommend iron chelation therapy to manage iron overload, however little is known about the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Myelodysplastic syndromes and the role of iron overload.

    ... of myelodysplastic syndromes (MDS) and iron overload , recent clinical findings that highlight the importance of ... and recommendations for initiating and maintaining iron chelation therapy (ICT) are summarized. SUMMARY: MDS are a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Impact of iron overload in myelodysplastic syndromes.

    ... red blood cell transfusions, which can lead to iron overload . Some patients may already have iron overload before ... MDS, especially those with lower-risk disease. Iron chelation therapy may be beneficial in these patients. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Iron overload in myelodysplastic syndromes: diagnosis and management.

    ... symptomatic management of refractory anemia . Iron overload ensues when the iron acquired from transfused RBCs exceeds body ... surveys, and phase II studies indicate that iron chelation therapy reduces iron load as measured by changes in serum ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Can iron overload in patients with lower-risk myelodysplastic syndromes be reduced using erythropoiesis-stimulating agents?

    ... Iron overload (IOL) portends inferior outcome in myelodysplastic ... had ferritin levels available, and were not receiving iron chelation therapy. Baseline characteristics were not significantly different ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Comparison of 24-month outcomes in chelated and non-chelated lower-risk patients with myelodysplastic syndromes in a prospective registry

    ... 600 lower-risk MDS patients (pts) with transfusional iron overload . Clinical outcomes were compared between chelated and ... MDS therapy was more common in chelated pts. At 24 months, chelation was associated with longer median overall survival (52.2 months vs. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management

    ... may include the use of prophylactic antibiotics and iron chelation. Management of progressive or refractory disease: There are ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Myelodysplastic syndromes: 2012 update on diagnosis, risk-stratification, and management

    ... may include the use of prophylactic antibiotics and iron chelation. Management of progressive or refractory disease: At the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Myelodysplastic syndromes: 2011 update on diagnosis, risk-stratification, and management

    ... may include the use of prophylactic antibiotics and iron chelation. MANAGEMENT OF PROGRESSIVE OR REFRACTORY DISEASE: At the ...

    Research Article last updated 07/20/2018 - 5:14pm.