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  1. A Phase 1, Multicenter, Open-Label, Dose-Escalation and Expansion, Safety, Pharmacokinetic, Pharmacodynamic, and Clinical Activity Study of Orally Administered AG-120 in Subjects with Advanced Hematologic Malignancies with an IDH1 Mutation

    ... prior to the start of therapy and on the first day of study drug administration. ... within 60 days of the first dose of AG-120, or subjects on immunosuppressive therapy post HSCT at the time of screening, or with ...

    Clinical Trial last updated 02/22/2017 - 11:21am.

  2. MEDALIST Trial

    ... (MDS) Associated Drug(s):  Luspatercept ... such as lenalidomide ], hypomethylating agents, or immunosuppressive therapy [IST]).      Previously treated with either ...

    Clinical Trial last updated 02/22/2017 - 11:42am.

  3. Pregnancy in Bone Marrow Failure Disease

    ... an allogeneic stem cell/ bone marrow transplant , the immunosuppressive medications may affect the ability to become pregnant. ... However, fetal outcomes are also improved with this drug. Use of lenalidomide (Revlimid®) during pregnancy is known ...

    Interview last updated 01/13/2017 - 9:28am.

  4. Eltrombopag for the treatment of aplastic anemia: current perspectives

    ... Journal Title:  Drug Des Devel Ther Primary ... young and medically fit patients with suitable donors and immunosuppressive therapy (IST) with antithymocyte globulin and ...

    Research Article last updated 11/01/2016 - 2:01pm.

  5. Long-term issues after Immunosuppressive therapy for Aplastic Anemia

    ... Journal Title:  Curr Drug Targets Primary Author:  ...

    Research Article last updated 06/23/2016 - 8:48am.

  6. Announcing AAMDSIF 2016 Research Awards

    ... allogeneic hematopoietic stem cell transplantation and immunosuppressive therapy based on two drugs: " cyclosporine " and ... results of standard therapy, by association with an other drug, called "eltrombopag". Researchers want to answer a simple question: Which ...

    Article last updated 06/09/2016 - 12:45pm.

  7. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... (MDS) Associated Drug(s):  Cyclophosphamide ... Active autoimmune disease requiring systemic immunosuppressive therapy Research participants will be excluded, ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  8. Pure Red Cell Aplasia (PRCA)

    ... goes away. Transient PRCA is usually triggered by a virus or drug. In most cases, when the virus clears, or the responsible drugs are ... medications are rarely used alone as a treatment. Immunosuppressive therapy may be used if the underlying cause of the PRCA is ...

    Topic section last updated 07/07/2016 - 3:14pm.

  9. Aplastic Anemia 101: Understanding Diagnosis and Treatment

    ... experience. He also covers common treatments such as immunosuppressive drug therapy , stem cell transplantation, and supportive therapies like ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  10. PNH 101: Understanding Diagnosis and Treatment

    ... covers treatment options, including eculizumab , immunosuppressive drug therapy , stem cell transplantation, and supportive therapies like ...

    LMS Item last updated 06/10/2016 - 1:24pm.