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  1. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... cells to break apart. Doctors call this breaking apart " hemolysis ." It happens because the surface of a person’s blood cells ... a few case reports of PNH patients getting flares of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ...

    Page last updated 07/20/2018 - 5:15pm.

  2. Valeria Visconte, PhD

    ... therapies to improve hemoglobin levels due to hemolysis or prevent thrombotic complications. Most successful to date were complement blockers designed for alleviation of hemolysis due to deficiency in complement. These therapies work by deactivating ...

    Grant Recipient last updated 07/27/2018 - 11:55am.

  3. Toward complement inhibition 2.0: Next generation anticomplement agents for paroxysmal nocturnal hemoglobinuria

    ... efficacy in prevention of C3-mediated extravascular hemolysis , in addition to inhibition of intravascular hemolysis, eventually leading to improved hematological responses. The ...

    Research Article last updated 04/11/2018 - 10:54am.

  4. Interviews with the Experts: Hemolysis in PNH and Beyond

    What is hemolysis and what its relationship to PNH? Hemolysis is a term we use to describe destruction and/or rupture of red blood ...

    Interview last updated 08/31/2016 - 8:40am.

  5. A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms

    ... of normal unless attributable to underlying disease, hemolysis or documented Gilbert’s syndrome. AST (SGOT)/ALT (SGPT) < ...

    Clinical Trial last updated 05/14/2018 - 2:02pm.

  6. A Phase III, International, Randomized, Controlled Study of Rigosertib versus Physician’s Choice of Treatment in Patients with Myelodysplastic Syndrome after Failure of a Hypomethylating Agent

    ... Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert’s disease i.          Alanine ...

    Clinical Trial last updated 05/04/2018 - 3:53pm.

  7. Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment

    ... characterized by complement-mediated intravascular hemolysis that is effectively treated with eculizumab . However, ... heterogeneous with some patients presenting residual hemolysis and requiring RBC transfusions. Recent reports have shown that both ...

    Research Article last updated 10/06/2016 - 8:50am.

  8. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a life-threating disease characterized by intravascular hemolysis , bone marrow (BM) failure, and venous thrombosis . ...

    Research Article last updated 07/27/2017 - 2:06pm.

  9. T Cell Transcriptomes from Paroxysmal Nocturnal Hemoglobinuria Patients Reveal Novel Signaling Pathways

    ... a life-threating disease characterized by intravascular hemolysis , bone marrow (BM) failure, and venous thrombosis . ...

    Research Article last updated 07/11/2017 - 10:43am.

  10. Flu Season Update

    ... There are also a few case reports of incidents of hemolysis (when red blood cells are destroyed) after receiving a flu shot. ... are not the same as randomized clinical trials, one case of hemolysis was severe enough to put the patient in the hospital. Thus some ...

    Facts for Life last updated 02/01/2018 - 3:49pm.