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  1. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... stem cell disorder characterized by intravascular hemolysis , aplasia and an increased risk of thrombosis . We describe ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Laboratory tests for paroxysmal nocturnal hemoglobinuria (PNH).

    ... the clone more sensitive to complement mediated hemolysis . The diagnosis of PNH may be difficult in some cases due a low ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... has been shown to improve anemia, decrease intravascular hemolysis and reduce the risk of thrombosis . DESIGN AND METHODS: ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... C5, has become the "gold standard" of treatment for hemolysis or significant disease-related complications in patients with ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria

    ... eculizumab (Soliris) reduces intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. A closer look at paroxysmal nocturnal hemoglobinuria

    ... in the past two decades. The associated intravascular hemolysis , hypercoagulablilty, and bone marrow failure result in a ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria.

    ... PNH red blood cells frequently manifests with chronic hemolysis , anemia , and thrombosis . Renal damage in PNH is ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders

    ... a sustained control of complement-mediated intravascular hemolysis , with a remarkable clinical benefit. Since then, different ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Paroxysmal nocturnal hemoglobinuria from bench to bedside

    ... on the surface of PNH cells leads to complement-mediated hemolysis . The release of free hemoglobin leads to scavenging of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine.

    ... lactate dehydrogenase , nor did they experience hemolysis or thrombosis , and they did not require specific ...

    Research Article last updated 07/20/2018 - 5:14pm.