Search | Page 3 | Aplastic Anemia and MDS International Foundation

Search

Search results

  1. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... that result in both intravascular and extravascular hemolysis . Free hemoglobin leads to nitric oxide depletion ... drug that in PNH has been shown to block complement-mediated hemolysis, reduce transfusion dependency, reduce thromboembolic complications ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Natural history of paroxysmal nocturnal hemoglobinuria clones in patients presenting as aplastic anemia.

    ... PNH clone size and the development of intravascular hemolysis , assessed by LDH values (Pearson Correlation Coefficient=0.80, ... granulocyte PNH size of 23% were the thresholds to predict hemolysis as measured by an elevated LDH (ROC analyses with AUC=0.96 for ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Paroxysmal nocturnal hemoglobinuria clones in children with acquired aplastic anemia: a multicentre study

    ... a GPI-negative population >10%, and laboratory signs of hemolysis without hemoglobinuria were considered affected by ... size. In this study monitoring for laboratory signs of hemolysis was sufficient to diagnose PNH in AA patients. The presence of minor ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria

    ... with PNH frequently experience complications of chronic hemolysis , recurrent thrombosis , marrow failure, serious ... therapy resulted in complete and sustained inhibition of hemolysis in all participants with a reduction of lactate dehydrogenase ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going

    ... a sustained control of complement-mediated intravascular hemolysis , with a remarkable clinical benefit. Anti-complement treatment ... patients receiving eculizumab, with adequate control of all hemolysis-associated symptoms even in almost all remaining patients. In ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Paroxysmal Nocturnal Hemoglobinuria: A Complement-Mediated Hemolytic Anemia

    ... for thrombosis and marrow failure. The hemolysis is largely mediated by the alternative pathway of complement. ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Deep sequencing reveals stepwise mutation acquisition in paroxysmal nocturnal hemoglobinuria

    ... stem cells that is associated with hemolysis , marrow failure, and thrombophilia. PNH has been considered a ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Paroxysmal nocturnal hemoglobinuria

    ... to uncontrolled complement activation that accounts for hemolysis and other PNH manifestations. GPI anchor protein deficiency is ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape

    ... susceptible to complement attack. Intravascular hemolysis via the membrane attack complex is a clinical hallmark of the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Long-term outcome of fludarabine-based reduced intensity allogeneic hematopoietic cell transplantation for debilitating paroxysmal nocturnal hemoglobinuria

    ... (PNH) is characterized by intravascular hemolysis , venous- thrombosis , and bone marrow failure . ...

    Research Article last updated 07/20/2018 - 5:15pm.