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  1. Phase I/II MAHCT w/ TCell Depleted Graft w/ Simultaneous Infusion Conventional and Regulatory T Cell

    ... may be included at the discretion of the PI or where hemolysis has been excluded Availability of an 6/6 HLA matched ...

    Clinical Trial last updated 05/09/2016 - 3:58pm.

  2. A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

    ... bilirubin within institutional limits unless due to hemolysis , Gilbert's syndrome, or ineffective erythropoiesis. ...

    Clinical Trial last updated 06/03/2016 - 3:09pm.

  3. Genetic Polymorphism of the Complement Receptor-1 (CR1) Gene Correlates with the Clinical Response to Eculizumab of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... of patients,  there is something called “extravascular hemolysis” which is keeping the hemoglobin from recovering fully. Here the ... factors at play in the group that had “extravascular hemolysis”. In fact, there is a gene called, CR1, which controls complement ...

    Research Review last updated 05/02/2016 - 9:25am.

  4. Transplantation of Partially Mismatched Related or Matched Unrelated Bone Marrow for Patients With Refractory Severe Aplastic Anemia

    ... ≤ 3.0 mg/dL (unless due to Gilbert's syndrome or hemolysis ), and ALT and AST ≤ 5 x ULN FEV1 and FVC > or = to 40% of ...

    Clinical Trial last updated 06/06/2016 - 2:42pm.

  5. RIC Transplant Using Haplo Donors

    ... liver function: bilirubin >2 mg/dl (not due to hemolysis , Gilbert's or primary malignancy) poor renal function: ...

    Clinical Trial last updated 04/29/2016 - 10:52am.

  6. Overlap Syndromes: When PNH Appears with Aplastic Anemia or MDS

    ... not to the level it should be. With PNH/MDS, even though hemolysis is a primary symptom of PNH, hemolysis can occur in rare patients with MDS for other reasons. This could be ...

    Interview last updated 05/14/2015 - 1:53pm.

  7. Phase I/II MEK162 Relapsed and/or Refractory Acute Myeloid Leukemia (AML) and Poor Prognosis, Not Suitable for or Unwilling to Receive Standard Therapy

    ... > 1.5 x ULN unless related to Gilbert's syndrome or hemolysis , AST and/or ALT > 2.5 X ULN, or for subjects with liver ...

    Clinical Trial last updated 06/06/2016 - 10:59am.

  8. Overlap Syndromes: When PNH Appears with Aplastic Anemia

    ... The reaction patients get with ATG can trigger hemolysis .  In patients a with large PNH red cell population who need ...

    Interview last updated 04/15/2015 - 9:39am.

  9. Bone Marrow and Kidney Transplant for Patients With Chronic Kidney Disease and Blood Disorders (BMT)

    ... bilirubin < 2.0 (unless diagnosis of Gilbert's or hemolysis is made) and AST, ALT, alkaline phosphatase all < 5x institutions ...

    Clinical Trial last updated 05/09/2016 - 3:36pm.

  10. Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders

    ... of their disease including thrombotic events, severe hemolysis or Budd Chiari syndrome are eligible; other patients may be ...

    Clinical Trial last updated 04/28/2016 - 2:45pm.