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  1. What is Flow Cytometry?

    ... the cells to break apart. This process is known as hemolysis . Relying on CD-55 and CD-59 deficient red cells may be ... (certain types of white cells that are not affected by hemolysis). This is done by utilizing a special substance known as FLAER, which ...

    Article last updated 10/10/2018 - 8:08am.

  2. Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated?

    Journal Title:  Ann Hematol Primary Author:  Bellido M Author(s):  Bellido M,...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Interviews with the Experts: Hemolysis in PNH and Beyond

    What is hemolysis and what its relationship to PNH? Hemolysis is a term we use to describe destruction and/or rupture of red blood ...

    Interview last updated 08/31/2016 - 8:40am.

  4. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Paroxysmal nocturnal hemoglobinuria and the complement system: recent insights and novel anticomplement strategies

    ... of PNH is chronic, complement-mediated, intravascular hemolysis , which results in anemia, hemoglobinuria, fatigue, and other hemolysis-related disabling symptoms. In addition, the peculiar thromboembolic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Peptide inhibitors of C3 activation as a novel strategy of complement inhibition for the treatment of paroxysmal nocturnal hemoglobinuria

    ... is characterized by complement-mediated intravascular hemolysis due to the lack of CD55 and CD59 on affected erythrocytes. The ... possibly leading to clinically meaningful extravascular hemolysis. We investigated the effect of the peptidic C3 inhibitor compstatin ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Successful pregnancy outcome in paroxysmal nocturnal hemoglobinuria (PNH) following escalated eculizumab dosing to control breakthrough hemolysis

    ... , she became pregnant. She developed breakthrough hemolysis at 20 weeks gestation. Pharmacokinetic and pharmacodynamic ... Escalation of her eculizumab dose successfully controlled hemolysis and restored therapeutic eculizumab level and activity. She ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Mechanisms and Clinical Implications of Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

    ... CD55 and CD59 on erythrocytes leads to intravascular hemolysis upon complement activation. Next to hemolysis, another prominent feature is a highly increased risk of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Thrombosis in patients with paroxysmal nocturnal hemoglobinuria.

    ... hemoglobinuria is a disorder associated with hemolysis , pancytopenia , and thrombosis due to the loss of ... of thrombosis is multifactorial. Although intravascular hemolysis has been implicated as the etiology , the effect of ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Clinical signs and symptoms associated with increased risk for thrombosis in patients with paroxysmal nocturnal hemoglobinuria from a Korean Registry.

    ... (PNH) is characterized by chronic, complement-mediated hemolysis , frequently leading to debilitating clinical symptoms and ... multivariate analysis showed that PNH patients with elevated hemolysis [ lactate dehydrogenase (LDH) levels ≥1.5 times the upper ...

    Research Article last updated 07/20/2018 - 5:15pm.