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  1. Predictors of Hemoglobin Response to Eculizumab Therapy in Paroxysmal Nocturnal Hemoglobinuria

    ... defined as transfusion independence with normal hemoglobin for age/sex, absence of symptoms, and lactate dehydrogenase ... red cell clone size following treatment. Normalization of hemoglobin with decrease in red cell clone size may predict complete response ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Paroxysmal Nocturnal Hemoglobinuria (PNH)

    ... immune system.  When red blood cells break apart, the hemoglobin inside is released. Hemoglobin is the red part of red blood cells that carries oxygen around the ...

    Page last updated 07/20/2018 - 5:15pm.

  3. Why are myelodysplastic syndromes unrecognized and underdiagnosed?: a primary care perspective

    ... in a 72-year-old man with several comorbidities and a hemoglobin level of 9.2 g/dL (historical levels, 10.8 to 11.2 g/dL). Despite the acute change in hemoglobin levels, and the presence of comorbid lung and heart disease, there ...

    Research Article last updated 07/20/2018 - 5:14pm.

  4. Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

    ... Heinrich-Heine-University Hospital, Dusseldorf, Germany. Hemoglobin levels were monitored longitudinally and analyzed by means of ... Cox proportional hazards regression models. Results. Hemoglobin levels lower than 9 g/dL in males (HR 5.56, P=0.018) and 8 g/dL in ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Clinical evaluation of combined azacitidine and entinostat on the induction of fetal hemoglobin in patients with acute myeloid leukemias and myelodysplastic syndromes

    Journal Title:  Leuk Lymphoma Primary Author:  Press KR Author(s):  Press KR,...

    Research Article last updated 08/03/2017 - 9:15am.

  6. Clinical outcome after failure of hypomethylating therapy for myelodysplastic syndromes

    ... in the first cohort of patients the goal is to improve hemoglobin levels and the quality of life while in higher risk patients ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Paroxysmal nocturnal hemoglobinuria and the age of therapeutic complement inhibition

    ... intravascular and extravascular hemolysis . Free hemoglobin leads to nitric oxide depletion that mediates the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Thrombosis in paroxysmal nocturnal hemoglobinuria.

    ... include platelet activation, toxicity of free hemoglobin , nitric oxide depletion, absence of other GPI-linked ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Prognostic Factors Associated With Disease Progression and Overall Survival in Patients With Myelodysplastic Syndromes Treated With Decitabine.

    ... study effect was associated with progression to AML. A hemoglobin value at least 10 g/dL, platelet count at least 50 × ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria

    ... hemoglobinuria (PNH), as well as stabilizing hemoglobin levels, improving fatigue and health-related quality of life, ...

    Research Article last updated 07/20/2018 - 5:14pm.