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  1. Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes

    ... that are characterized by defective bone marrow hematopoiesis and by the occurrence of intramedullary apoptosis . ... that the dysregulation of these molecules leads to abnormal hematopoiesis, unbalanced cell death and proliferation in patients' bone marrow ...

    Research Article last updated 04/29/2016 - 11:35am.

  2. Red Blood Cell Transfusion Dependency and Hyperferritinemia Are Associated with Impaired Survival in Patients Diagnosed with Myelodysplastic Syndromes: Results from the First Polish MDS-PALG Registry

    ... clonal stem cell disorders characterized by ineffective hematopoiesis , cytopenias and a risk of progression to acute myeloid ...

    Research Article last updated 10/06/2016 - 1:01pm.

  3. Implications of molecular genetic diversity in myelodysplastic syndromes

    ... with unexplained cytopenias have a high rate of clonal hematopoiesis that may be an important risk factor to identify clinically. ...

    Research Article last updated 12/09/2016 - 2:54pm.

  4. Connect MDS/AML: design of the myelodysplastic syndromes and acute myeloid leukemia disease registry, a prospective observational cohort study.

    ... in which outgrowth of neoplastic clones disrupts normal hematopoiesis . Some patients with unexplained persistent cytopenias may not ...

    Research Article last updated 09/19/2016 - 11:05am.

  5. Deregulated microRNA expression and its pathogenetic implications for myelodysplastic syndromes

    ... stem cell disorders characterized by ineffective hematopoiesis , cytopenias. MicroRNAs (miRNAs) are short non-coding RNA ...

    Research Article last updated 08/15/2016 - 11:30am.

  6. Mutational hierarchies in myelodysplastic syndromes dynamically adapt and evolve upon therapy response and failure

    ... the hierarchical organization of malignant clones in the hematopoiesis of myelodysplastic syndromes (MDS) and its impact on ...

    Research Article last updated 07/18/2016 - 11:18am.

  7. Analysis of allogeneic hematopoietic stem cell transplantation with high-dose cyclophosphamide-induced immune tolerance for severe aplastic anemia

    ... was confirmed by the evidence of 100 % donor hematopoiesis ; T lymphocyte subset counts also increased ...

    Research Article last updated 11/01/2016 - 1:59pm.

  8. Myelodysplastic syndromes: pathophysiology, clinical and biological features

    ... or more myeloid lineages responsible for an ineffective hematopoiesis , and therefore cytopenias of central origin contrasting with ...

    Research Article last updated 04/29/2016 - 11:32am.

  9. Unraveling Myelodysplastic Syndromes: Current Knowledge and Future Directions

    ... prognoses. The main features of MDS are ineffective hematopoiesis and aberrant myeloid differentiation. Furthermore, MDS are ...

    Research Article last updated 04/29/2016 - 11:23am.

  10. Pexmetinib: a novel dual inhibitor of Tie-2 and p38 MAPK with efficacy in preclinical models of myelodysplastic syndromes and acute myeloid leukemia

    ... of primary MDS specimens with this compound stimulated hematopoiesis . Our results provide preclinical proof of concept for ...

    Research Article last updated 07/18/2016 - 11:12am.