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  1. Kate MacNamara, PhD

    ... identify novel pathways that can be targeted to rescue hematopoiesis in patients with bone marrow failure. ... macrophages drive the loss of hematopoietic cells and hematopoiesis . Final ...

    Grant Recipient last updated 08/16/2018 - 12:00pm.

  2. Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

    ... acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis ... morphology of blood and marrow cells, and clonal hematopoiesis, most individuals who acquire clonal hematopoiesis during aging ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia

    ... destruction of early hematopoietic cells. Clonal hematopoiesis is a late complication, seen in 20-25% of older patients. We hypothesized that clonal hematopoiesis in aAA is a more general phenomenon, which can arise early in ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Eltrombopag restores tri-lineage hematopoiesis in refractory severe aplastic anemia which can be sustained on discontinuation of drug

    ... multilineage responses, and maintenance of normalized hematopoiesis off treatment. This study is registered at ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Eltrombopag and improved hematopoiesis in refractory aplastic anemia

    ... bone marrow biopsies showed normalization of trilineage hematopoiesis in patients who had a response, without increased ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

    Journal Title:  N Engl J Med Primary Author:  Mufti GJ Author(s):  Mufti GJ, ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Functional characteristics of mesenchymal stem cells derived from bone marrow of patients with myelodysplastic syndromes

    ... of their capabilities of immunomodulatory and supporting hematopoiesis . Nevertheless, it is unclear whether the characteristics of ... appeared to be impaired in immunomodulatory and supporting hematopoiesis function. Although, MDS-MSCs could express hematopoietic ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia.

    ... a substantial proportion of AA patients harbors clonal hematopoiesis characterized by the presence of acquired copy number-neutral ... of AA patients. These findings indicate that the 6pLOH(+) hematopoiesis found in AA represents 'escape' hematopoiesis from the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. When to treat myelodysplastic syndromes.

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Myelodysplastic syndromes: where do we go from here?

    ... characterized by morphologic dysplasia, aberrant hematopoiesis and a variable risk of progression to acute myeloid leukemia. These syndromes have a complex pathobiology, and ineffective hematopoiesis is a well-recognized feature of all of them. Normal blood cell ...

    Research Article last updated 07/20/2018 - 5:14pm.