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  1. Successful Use of Eculizumab in a Pediatric Patient Treated for Paroxysmal Nocturnal Hemoglobinuria

    ... in adulthood and are very rarely reported in children. Eculizumab , a humanized monoclonal antibody targeting and ... disease-related complications in patients with PNH. Although eculizumab is not licensed for use in pediatrics, we report a young PNH patient ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Eculizumab: a guide to its use in paroxysmal nocturnal hemoglobinuria

    ... The targeted terminal complement inhibitor eculizumab (Soliris) reduces intravascular hemolysis in patients ... reducing the requirement for packed red cell transfusions. Eculizumab is generally well tolerated in patients with PNH, although the risk ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Improving cytopenia with splenic artery embolization in a patient with paroxysmal nocturnal hemoglobinuria on eculizumab

    ... under treatment with the anti-complement antibody eculizumab who developed pancytopenia , requiring blood ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Managing a pregnant patient with paroxysmal nocturnal hemoglobinuria in the era of eculizumab.

    ... an increased rate of premature labor and fetal loss. Eculizumab , a humanized monoclonal antibody directed against the terminal ... has revolutionized treatment of PNH. However, the role of eculizumab in pregnancy is unclear. We review the current strategies for the ...

    Research Article last updated 07/20/2018 - 5:14pm.

  5. Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience

    ... 27 years at pregnancy. None of these women had received eculizumab during their pregnancy. Maternal complications, consisting ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Thrombotic complications without evidence of hemolysis in paroxysmal nocturnal hemoglobinuria: is eculizumab indicated?

    Journal Title:  Ann Hematol Primary Author:  Bellido M Author(s):  Bellido M,...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Eculizumab treatment of paroxysmal nocturnal hemoglobinuria presenting as moyamoya syndrome in a 9-year-old male.

    Journal Title:  Pediatr Blood Cancer Primary Author:  Yen TA, Lu MY, Kuo MF, Huang CC, Chen JS, Yang YL ...

    Research Article last updated 07/20/2018 - 5:14pm.

  8. Paroxysmal nocturnal hemoglobinuria and eculizumab.

    Journal Title:  Haematologica Primary Author:  Luzzatto L Author(s):  Luzzatt...

    Research Article last updated 07/20/2018 - 5:14pm.

  9. Successful discontinuation of anticoagulation following eculizumab administration in paroxysmal nocturnal hemoglobinuria.

    Journal Title:  Am J Hematol Primary Author:  Emadi A Author(s):  Emadi A, Br...

    Research Article last updated 07/20/2018 - 5:14pm.

  10. Hemolytic anemia after eculizumab in paroxysmal nocturnal hemoglobinuria.

    Journal Title:  N Engl J Med Primary Author:  Berzuini A Author(s):  Berzuini...

    Research Article last updated 07/20/2018 - 5:14pm.