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  1. Clinical Effects of Driver Somatic Mutations on the Outcomes of Patients With Myelodysplastic Syndromes Treated With Allogeneic Hematopoietic Stem-Cell Transplantation

    ... in genes of RNA splicing machinery, TP53-mutated AML, or de novo AML) was an independent predictor of posttransplantation outcome (P = ...

    Research Article last updated 10/06/2016 - 3:00pm.

  2. Top expert calls future MDS/AML care “promising”

    ... both patients who present with either high- or low-risk de novo , and patients who have actually been treated with these ...

    Article last updated 11/02/2016 - 11:28am.

  3. Recurrent and Secondary MDS

    ... post-treatment. What is the difference between de novo MDS and secondary MDS ? De novo MDS refers to an MDS that ...

    Interview last updated 10/24/2012 - 1:12pm.

  4. Efficacy of Oral Azacitidine Plus Best Supportive Care as Maintenance Therapy in Subjects With Acute Myeloid Leukemia in Complete Remission (QUAZAR AML-001)

    ... 460 subjects, aged 55 or older, with a diagnosis of de novo AML (Acute Myeloid Leukemia) or AML secondary to prior myelodysplastic ...

    Clinical Trial last updated 04/29/2016 - 8:39am.

  5. MDS: Causes

    ... know the exact cause of MDS. These cases are called de novo MDS. We do know that certain lifestyle factors are linked to MDS.  ...

    Page last updated 02/25/2015 - 11:31am.

  6. The National Myelodysplastic Syndromes Natural History Study

    ... bone marrow assessments, or diagnosed with de novo or therapy-related MDS within 6-months of enrollment per the ...

    Clinical Trial last updated 02/23/2017 - 1:36pm.

  7. Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

    ... refractory CD123+ acute myeloid leukemia (AML) de novo , or secondary Relapsed AML is defined as patients that had ...

    Clinical Trial last updated 07/14/2016 - 4:08pm.

  8. What is Secondary MDS? Everything You Need to Know

    ... will understand: The difference between primary ( de novo ) and secondary MDS Factors that could possibly affect treatment ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  9. What is Secondary MDS? Everything You Need to Know

    ... will understand: The difference between primary ( de novo ) and secondary MDS Factors that could possibly affect treatment ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  10. Prior allogeneic transplant Karnofsky Performance Score < 70% Active central nervous system (CNS) involvement by malignant cells Patients with uncontrolled bacterial, viral or fungal infections (currently taking medication and with progre

    ... diagnoses and/or treatment plans: Newly diagnosed de novo AML First or subsequent relapse of AML Secondary AML ...

    Clinical Trial last updated 06/06/2016 - 2:05pm.