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  1. Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies

    ... first remission (with intermediate-risk or high-risk cytogenetics , flt3 mutation positive and/or evidence of minimal ...

    Clinical Trial last updated 06/06/2016 - 12:58pm.

  2. Natural Killer (NK) Cells With HLA Compatible Hematopoietic Transplantation for High Risk Myeloid Malignancies

    ... the following high risk features defined as: (i) Adverse cytogenetics : -5, del 5q, -7, del7q, abnormalities involving 3q, 9q, 11q, ...

    Clinical Trial last updated 06/06/2016 - 1:18pm.

  3. MDS—The Past 40 Years. A Look at the Emerging Awareness and Classification of Myelodysplastic Syndromes.

    ... two other measures.  One is karyotype (also known as cytogenetics ) or abnormalities in bone marrow chromosomes . The ... The IPSS-R includes increased importance assigned to cytogenetics. Risk categories expand from four to five with this revised ...

    Page last updated 10/19/2015 - 2:29pm.

  4. Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

    ... defined by at least one of the following: Adverse cytogenetics such as t(9;22), t(1;19), t(4;11), mixed lineage leukemia ... (FAB) M6 or M7 leukemia, or Adverse cytogenetics for overall survival such as: Those associated with MDS ...

    Clinical Trial last updated 04/29/2016 - 3:26pm.

  5. Allogeneic Bone Marrow Transplantation Using Less Intensive Therapy

    ... requirements not responsive to therapy, or high risk cytogenetics . Blasts must be less than 5%. If >5% requires therapy ...

    Clinical Trial last updated 05/02/2016 - 2:20pm.

  6. Nonmyeloablative Haploidentical Transplant Followed by MLN9708

    ... subsequently entered into a CR(OR) 1st CR with poor risk cytogenetics or molecular markers; or arising from preceding hematological ... Syndrome (treatment-related, monosomy 7 or complex cytogenetics, IPSS score of 1.5 or greater, Chronic myelomonocytic leukemia ...

    Clinical Trial last updated 04/29/2016 - 1:05pm.

  7. Fludarabine/Clofarabine/Busulfan Combined With SAHA in Acute Leukemia

    ... after one course of induction and with favorable cytogenetics [t(8;21, inv 16, or t(15;17)] and/or molecular profile (NPM1). ...

    Clinical Trial last updated 06/06/2016 - 11:07am.

  8. Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    ... AML in CR1 must have one of the following: Adverse cytogenetics (as evaluated by history) as defined as complex karyotype (> 3 ... with ALL in CR1 must have one of the following: Adverse cytogenetics defined as translocations involving t(4;11), t(1;19), t(8;14), ...

    Clinical Trial last updated 04/29/2016 - 1:00pm.

  9. Transplantation Update

    ... patients who have what we consider complex,  high-risk cytogenetics ( monosomy 7 and others) which was the major cause of ...

    Interview last updated 05/14/2015 - 2:42pm.

  10. HLA-Compatible Related or Unrelated Donors With CD34+ Enriched, T-cell Depleted Peripheral Blood Stem Cells Isolated by the CliniMACS System in the Treatment of Patients With Hematologic Malignancies

    ... additional chemotherapy. Patients with high risk cytogenetics at diagnosis must have achieved a partial response following ...

    Clinical Trial last updated 04/29/2016 - 3:18pm.