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  1. Discontinuation of hypomethylating agent therapy in patients with myelodysplastic syndromes or acute myelogenous leukemia in complete remission or partial response: Retrospective analysis of survival after long-term follow-up

    ... (median: 4 months [95% CI: 1-8]) (p=0.043). Poor-risk cytogenetics were also associated with lower 1-year OS (33% versus 69%; ...

    Research Article last updated 07/20/2018 - 5:15pm.

  2. Multicentre validation of a reproducible flow cytometric score for the diagnosis of low-risk myelodysplastic syndromes: results of a European LeukemiaNET study

    ... (P=.001), transfusion-dependency (P=.02), and poor risk- cytogenetics (P=.04). Comparable sensitivity and specificity were obtained ... syndrome, especially when morphology and cytogenetics are indeterminate. ...

    Research Article last updated 07/20/2018 - 5:14pm.

  3. Multiparameter flow cytometry provides independent prognostic information in patients with suspected myelodysplastic syndromes: A study on 804 patients

    ... standard diagnostic parameters cytomorphology and cytogenetics . MFC may therefore be considered an additional tool in the ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Who benefits from allogeneic transplantation for myelodysplastic syndromes?: new insights

    ... is mandatory and stratification according to age, cytogenetics , cytopenias, disease-related quality of life, and available ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. Association of telomere length of peripheral blood leukocytes with hematopoietic relapse, malignant transformation, and survival in severe aplastic anemia.

    ... = .009), and evolution to monosomy 7 or complex cytogenetics was more common in the first quartile (18.8%; 95% CI, ...

    Research Article last updated 07/20/2018 - 5:14pm.

  6. Value of allogeneic versus autologous stem cell transplantation and chemotherapy in patients with myelodysplastic syndromes and secondary acute myeloid leukemia. Final results of a prospective randomized European Intergroup Trial.

    ... of myelodysplastic syndromes with intermediate/high-risk cytogenetics . Autologous peripheral blood stem cell transplantation does ...

    Research Article last updated 07/20/2018 - 5:14pm.

  7. Types

    ... patients a score based on three factors: cytogenetics (changes in cell DNA) cytopenias (low blood cell counts) ... 2 3 4 Cytogenetics Very Good   Good   ...

    Topic section last updated 07/20/2018 - 5:15pm.

  8. Somatic HLA mutations expose the role of class I–mediated autoimmunity in aplastic anemia and its clonal complications

    ... complications as assessed by WES, SNP-A, and metaphase cytogenetics , and more frequent secondary MDS . The finding of ...

    Research Article last updated 10/23/2017 - 10:56am.

  9. Outcome of patients treated for myelodysplastic syndromes with 5q deletion after failure of lenalidomide therapy.

    ... progression after LEN failure, and unfavorable cytogenetics . Among the treatment strategies, we observed a relatively ...

    Research Article last updated 07/11/2017 - 10:11am.

  10. Recurrent Cytogenetic Abnormalities in Myelodysplastic Syndromes

    ... with this condition, have now been identified. Cytogenetics forms the cornerstone of the most widely adopted prognostic ... in MDS pathogenesis. Integration of molecular genetics and cytogenetics holds much promise for improving clinical care and outcomes for ...

    Research Article last updated 01/26/2017 - 11:01am.