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  1. SNP array-based karyotyping: differences and similarities between aplastic anemia and hypocellular myelodysplastic syndromes.

    ... polymorphism (SNP) arrays, complementing routine cytogenetics . We hypothesized that clinically important cryptic clonal ... in 5/14 (36%) patients with normal/non-informative routine cytogenetics. In a subset of AA patients studied at presentation, persistent ...

    Research Article last updated 07/20/2018 - 5:14pm.

  2. Non-t(6;9) and Non-Inv(3) Balanced Chromosomal Rearrangements Are Associated With Poor Survival Outcomes in Myelodysplastic Syndromes

    ... BACKGROUND: Cytogenetics is an important predictor of survival in patients with ... overall survival (OS) similar to patients with poor risk cytogenetics, defined according to the International Prognostic Scoring ...

    Research Article last updated 07/20/2018 - 5:15pm.

  3. Relapse after Allogeneic Hematopoietic Cell Transplantation for Myelodysplastic Syndromes: Analysis of Late Relapse Using Comparative Karyotype and Chromosome Genome Array Testing

    ... proportion of patients with early relapse had high-risk cytogenetics compared with patients with late relapse (P = .009). ... late relapse showed molecular differences not detectable by cytogenetics between the pre-HCT clones and the clones at relapse. These data ...

    Research Article last updated 07/20/2018 - 5:15pm.

  4. Impact of TP53 mutation variant allele frequency on phenotype and outcomes in myelodysplastic syndromes

    ... When parsed by VAF, TP53 VAF predicted for complex cytogenetics in both the training (P=0.001) and validation set (P<0.0001). ...

    Research Article last updated 07/20/2018 - 5:15pm.

  5. The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes

    ... patients with AML and MDS, including those with normal cytogenetics . DNA-level mutations in several of these genes including ...

    Research Article last updated 07/20/2018 - 5:15pm.

  6. Response to azacitidine is independent of p53 expression in higher-risk myelodysplastic syndromes and secondary acute myeloid leukemia.

    ... patients were p53-positive and most had very poor risk cytogenetics with chromosome 5 aberrations and monosomal karyotypes. The ...

    Research Article last updated 07/20/2018 - 5:15pm.

  7. Standardizing the Initial Evaluation for Myelodysplastic Syndromes.

    ... using laboratory results, morphology and cytogenetics . More sophisticated technologies, including multi-color ...

    Research Article last updated 07/20/2018 - 5:15pm.

  8. Cutting edge: flow cytometry in myelodysplastic syndromes

    ... syndromes (MDS), especially when cytomorphology and cytogenetics are inconclusive. Minimal requirements to analyze dysplasia ...

    Research Article last updated 07/20/2018 - 5:15pm.

  9. Recent advances in the management of therapy-related myelodysplastic syndromes and acute myeloid leukemia.

    ... Multiple retrospective studies have identified poor-risk cytogenetics , chemotherapy resistance, comorbidities from prior ...

    Research Article last updated 07/20/2018 - 5:15pm.

  10. Improving the diagnosis and treatment of patients with myelodysplastic syndromes through a performance improvement initiative

    ... careful consideration of pathologic features and cytogenetics , and treatment options vary based on disease severity. A ...

    Research Article last updated 07/20/2018 - 5:15pm.