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  1. EHA S826: Eltrombopag Added to Standard Immunosuppression as First Treatment in Severe Aplastic Anemia

    ... therapy with horse antithymocyte globulin and cyclosporine in two groups of patients. The first cohort included 30 ... first cohort tolerated the combination of eltrombopag and cyclosporine well, and only three patients stopped the treatment before six ...

    Research Review last updated 05/02/2016 - 9:10am.

  2. Extended Dosing With Eltrombopag for Severe Aplastic Anemia

    ... do not respond to a single course of horse ATG and cyclosporine and have persistent severe cytopenias. Among patients who do ... patients either relapse or are dependent on continued cyclosporine administration. Patients with refractory severe cytopenias ...

    Clinical Trial last updated 04/26/2016 - 9:36am.

  3. Cytoxan, Fludara, and Antithymocyte Globulin Conditioning Followed By Stem Cell Transplant in Treating Fanconi Anemia

    ... Graft-versus-host disease prophylaxis: Patients receive cyclosporine IV over 2 hours or orally every 8-12 hours beginning on day -3 ... count > or = 2.5 x 10^9/L Other Name: G-CSF Drug: cyclosporine cyclosporine IV over 2 hours or orally every 8-12 hours ...

    Clinical Trial last updated 04/28/2016 - 8:53am.

  4. Abatacept Reduced Intensity for Non-Malignant Diseases (Aba NMD)

    ... to a standard post-transplant GVHD prophylaxis regimen, cyclosporine and mycophenolate mofetil, to improve disease-free survival ... +5, +14, +28, +56 and +84). Abatacept will be combined with cyclosporine and mycophenolate mofetil. Specific Aim #2: to compare the ...

    Clinical Trial last updated 04/27/2016 - 2:40pm.

  5. FAQs

    ... stem cells . ATG ( antithymocyte globulin ) and cyclosporine are the medicines typically used. Bone marrow ... These medicines include ATG (antithymocyte globulin) and cyclosporine. Drug therapies approved specifically to treat MDS stop ...

    Topic section last updated 03/02/2016 - 11:42am.

  6. HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy (RAFA)

    ... use of lower doses of busulfan and the elimination of cyclosporine will further reduce transplant-related side effects for ...

    Clinical Trial last updated 05/09/2016 - 3:19pm.

  7. Overview of stem cell transplantation for aplastic anemia

    ... immune system, antithymocyte globulin (ATG) plus cyclosporine (CsA), or an allogeneic hematopoietic stem cell ...

    Research Review last updated 05/02/2016 - 9:31am.

  8. European Study of Horse ATG vs. Rabbit ATG for Treatment of Aplastic Anemia

    ... is a combination of anti-thymocyte globulin (ATG) and cyclosporine (CsA). Combining these two drugs results in response rates of ...

    Research Review last updated 05/02/2016 - 9:31am.

  9. Even "Moderate" Dose Cyclophosphamide for Severe Aplastic Anemia Is Associated with Significant Toxicities and Does Not Prevent Relapse and Clonal Evolution

    ... infections) compared to standard of care with horse-ATG/ cyclosporine .  These toxicities far outweighed the reduction in clonal ... of lower dose cyclophosphamide (30mg/kg/day x 4 days) plus cyclosporine, the benefits of cyclophosphamide were maintained with a reduction ...

    Research Review last updated 05/02/2016 - 9:23am.

  10. Hematopoietic Stem Cell Transplantation in High Risk Patients With Fanconi Anemia

    ... Graft-vs-host disease prophylaxis: Patients receive cyclosporine IV over 2 hours twice daily on days -3 to 100 (if patient has ...

    Clinical Trial last updated 04/28/2016 - 8:49am.