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  1. PNH: Diagnosis

    ... Type I cells: These cells respond in a healthy way to the complement system. They are normal cells. PNH II cells, or Type II cells: These cells ...

    Page last updated 01/20/2015 - 4:48pm.

  2. Therapies

    ... Agency (EMEA) to treat PNH. It works by making your complement system less active. ...

    Page last updated 03/18/2016 - 11:26am.

  3. What are the treatments for PNH?

    ... anemia . This therapy uses medicines to keep the immune system from attacking the bone marrow. Antithymocyte globulin (ATG) and ... to treat PNH. It works by slowing down your body’s complement system , which is part of your immune system. This reduces ...

    FAQ last updated 03/15/2016 - 11:32pm.

  4. PNH: Causes

    ... of proteins that protect normal red blood cells from the complement system. So they may be attacked and destroyed by the complement system ...

    Page last updated 06/29/2015 - 8:44am.

  5. Soliris

    ... Agency (EMEA) to treat PNH. It works by making your complement system less active. Benefits of Soliris Soliris has many benefits. ...

    Page last updated 06/29/2015 - 9:07am.

  6. Prednisone

    ... hemolysis caused by PNH. It may make the complement system less active. It may also increase counts of white blood cells and ...

    Page last updated 01/20/2015 - 4:57pm.

  7. FAQs

    ... experts believe aplastic anemia occurs because your immune system attacks and kills your stem cells in your bone marrow. This causes you ... Agency (EMEA) to treat PNH. It works by making your complement system (a part of your immune system) less active. This reduces ...

    Topic section last updated 03/02/2016 - 11:42am.

  8. Youmna Kfoury, PhD

    ... libraries, we used the Clontech SMARTer Ultra low input RNA system which were then sequenced on Illumina Hiseq2000 instrument, resulting in ... the co-culture. In the case of up regulated genes we will complement our CRISPR based knock out with an over expression strategy. ...

    Grant Recipient last updated 12/15/2016 - 12:56pm.

  9. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... anemia is a disease where the patients’ immune system attacks his or her own bone marrow . Normally, such an attack ... normally prevent the red cell from being broken down by complement proteins. In a way, PNH could also be thought of as an auto-immune ...

    Research Review last updated 05/02/2016 - 9:26am.

  10. Safety and Effect of GL-ONC1 Administered IV With or Without Eculizumab Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery

    ... drug is designed to inhibit the activity of a protein called complement. Complement is part of the body's immune system that destroys and removes foreign particles. Evidence from laboratory ...

    Clinical Trial last updated 04/28/2016 - 1:57pm.