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  1. Chao-Yie Yang, MD, PhD

    ... Discovery of small molecule complement inhibitors as the treatment for PNH ... inhibits C3, a key component of the complement activation system responsible for the cause of PNH, and the use of AMY-101 is a new ...

    Grant Recipient last updated 08/09/2016 - 1:02pm.

  2. Understanding the Compliment System and the PNH Clone

    ... The complement system is a group of proteins in the blood. They help support (complement) ...

    LMS Item last updated 06/10/2016 - 1:24pm.

  3. Complement Blockade with a C1 Esterase Inhibitor in Paroxysmal Nocturnal Hemoglobinuria

    ... normally protect red blood cells from destruction by the complement system . The proteins in the complement system normally fight foreign ...

    Research Review last updated 05/02/2016 - 9:21am.

  4. Novel Complement Modulators for Paroxysmal Nocturnal Hemoglobinuria: Peptide and Protein Inhibitors of C3 Convertase Prevent Both Surface C3 Deposition and Subsequent Hemolysis of Affected Erythrocytes in Vitro

    ... this will be because eculizumab only partially blocks the complement proteins. It turns out that there are two key complement proteins, ... they both work at an early stage in the complement system , these compounds might prevent both types of hemolysis (breakdown in ...

    Research Review last updated 05/02/2016 - 9:25am.

  5. PNH - Basics

    ... missing a protein that protects them from the body's immune system.  When red blood cells break apart, the hemoglobin inside is ... The Complement System The complement ...

    Topic section last updated 04/05/2016 - 4:02pm.

  6. Autoreactive T Cells From Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Specifically Recognize Glycosyl- Phosphatidyl-Inositol (GPI)

    ... anemia is a disease where the patients’ immune system attacks his or her own bone marrow . Normally, such an attack ... normally prevent the red cell from being broken down by complement proteins. In a way, PNH could also be thought of as an auto-immune ...

    Research Review last updated 05/02/2016 - 9:26am.

  7. Safety and Effect of GL-ONC1 Administered IV With or Without Eculizumab Prior to Surgery to Patients With Solid Organ Cancers Undergoing Surgery

    ... drug is designed to inhibit the activity of a protein called complement. Complement is part of the body's immune system that destroys and removes foreign particles. Evidence from laboratory ...

    Clinical Trial last updated 04/28/2016 - 1:57pm.

  8. Symptoms

    ... apart of red blood cells. Hemolysis happens when the complement system , a part of your body’s immune system, becomes more active and ...

    Topic section last updated 03/29/2016 - 6:18pm.

  9. Diagnosis

    ... cells are normal. They respond in a healthy way to the complement system . PNH II cells, or Type II cells:  These cells are partially ...

    Topic section last updated 03/10/2016 - 11:04pm.

  10. Eculizumab

    ... Eculizumab causes the complement system , a part of your immune system, to be less active. By doing this it ...

    Drug last updated 03/24/2016 - 12:32pm.